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Tbio
WIPI1
WD repeat domain phosphoinositide-interacting protein 1

Protein Summary
Description
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262139
  • ENSP00000262139
  • ENSG00000070540

Symbol
  • WIPI49
  • ATG18
  • ATG18A
  • WIPI49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.91
small molecule perturbation
0.86
biological process
0.76
cellular component
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
89
vitamin D measurement
1
1
1
66
glomerular filtration rate
2
2
2
34.8
reticulocyte measurement
1
1
1
23
lymphocyte percentage of leukocytes
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
89
vitamin D measurement
1
66
glomerular filtration rate
2
34.8
reticulocyte measurement
1
23
lymphocyte percentage of leukocytes
1
10.7
Pathways (11)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
IRE1alpha activates chaperones
Reactome
Macroautophagy
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
IRE1alpha activates chaperones
Macroautophagy
Metabolism of proteins
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (100)
1 – 10 of 100
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.999882176
p_ni: 0.000117824
Score: 0.222
Data Source: BioPlex,STRINGDB
RACK1
Tbio
Novelty: 0.00200617
p_int: 0.999454234
p_ni: 0.000545766
Score: 0.34
Data Source: BioPlex,STRINGDB
DNASE2B
Tbio
Family: Enzyme
Novelty: 0.02506932
p_int: 0.992436366
p_ni: 0.000025632
p_wrong: 0.007538002
Score: 0.189
Data Source: BioPlex,STRINGDB
CEP76
Tdark
Novelty: 0.3880387
p_int: 0.961767747
p_ni: 0.038232248
p_wrong: 5e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
ATG2B
Tbio
Novelty: 0.04963717
Score: 0.977
Data Source: STRINGDB
ATG2A
Tbio
Novelty: 0.06244231
Score: 0.975
Data Source: STRINGDB
ATG16L1
Tbio
Novelty: 0.0031765
Score: 0.956
Data Source: STRINGDB
ATG12
Tbio
Novelty: 0.00304298
Score: 0.943
Data Source: STRINGDB
ATG7
Tbio
Novelty: 0.00120728
Score: 0.937
Data Source: STRINGDB
ATG5
Tbio
Novelty: 0.00081472
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.02

PubMed score by year
PubTator Score  26.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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