Protein Summary
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).
- ENST00000334056
- ENSP00000335628
- ENSG00000163806
- ENST00000379579
- ENSP00000368898
- SPDY1
- SPY1
- SPY1
- SPDY1
- RINGO3
- RINGOA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.79 | ||
transcription factor | 0.65 | ||
tissue sample | 0.59 | ||
biological process | 0.55 | ||
cell type or tissue | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.93 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.93 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (31)
Nearest Tclin Targets (6)
Upstream (6)
1 – 5 of 6
Pathways (2)
KEGG (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Oocyte meiosis | ||||
KEGG | Progesterone-mediated oocyte maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Oocyte meiosis | ||||
Progesterone-mediated oocyte maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (2)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 5 | 81.2 | |||||
viral load | 1 | 1 | 1 | 71.3 | |||||
body mass index | 2 | 2 | 2 | 60.9 | |||||
bone density | 1 | 1 | 1 | 58.4 | |||||
1 | 1 | 0 | 1.1 | 33.1 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 5 | 81.2 | |||||
viral load | 1 | 71.3 | |||||
body mass index | 2 | 60.9 | |||||
bone density | 1 | 58.4 | |||||
0 | 1.1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | speedy/RINGO cell cycle regulator family member A | VGNC:382 | 459119 | |||||
Macaque | speedy/RINGO cell cycle regulator family member A | 703530 | ||||||
Mouse | MGI:1918141 | 70891 | ||||||
Rat | RGD:621730 | 192209 | ||||||
Dog | speedy/RINGO cell cycle regulator family member A | VGNC:46728 | 100688090 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | speedy/RINGO cell cycle regulator family member A | |||||
Macaque | speedy/RINGO cell cycle regulator family member A | |||||
Mouse | ||||||
Rat | ||||||
Dog | speedy/RINGO cell cycle regulator family member A | |||||
Publication Statistics
PubMed Score 60.93
PubMed score by year
PubTator Score 24.74
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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