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Tbio
SPDYA
Speedy protein A

Protein Summary
Description
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334056
  • ENSP00000335628
  • ENSG00000163806
  • ENST00000379579
  • ENSP00000368898

Symbol
  • SPDY1
  • SPY1
  • SPY1
  • SPDY1
  • RINGO3
  • RINGOA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor
0.65
tissue sample
0.59
biological process
0.55
cell type or tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.93   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.93   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.991
Data Source:  STRINGDB
CDKN1B
Tbio
Family:  Enzyme
Novelty:  0.00069449
Score:  0.964
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.907
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.737
Data Source:  STRINGDB
GHDC
Tbio
Novelty:  0.08423152
Score:  0.713
Data Source:  STRINGDB
TESMIN
Tbio
Novelty:  0.06186518
Score:  0.686
Data Source:  STRINGDB
CLIP3
Tbio
Novelty:  0.08151142
Score:  0.682
Data Source:  STRINGDB
EHD2
Tbio
Novelty:  0.02724854
Score:  0.649
Data Source:  STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.62
Data Source:  STRINGDB
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
Score:  0.564
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
PGR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  4
Common Pathways:  2
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  2
CALM3
Tclin
Family:  Other
KEGG Distance:  4
Common Pathways:  1
CALM1
Tclin
Family:  Other
KEGG Distance:  4
Common Pathways:  1
AR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  4
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
81.2
viral load
1
1
1
71.3
body mass index
2
2
2
60.9
bone density
1
1
1
58.4
1
1
0
1.1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
81.2
viral load
1
71.3
body mass index
2
60.9
bone density
1
58.4
0
1.1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
speedy/RINGO cell cycle regulator family member A
VGNC:382
459119
Macaque
speedy/RINGO cell cycle regulator family member A
703530
Mouse
MGI:1918141
70891
Rat
RGD:621730
192209
Dog
speedy/RINGO cell cycle regulator family member A
VGNC:46728
100688090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
speedy/RINGO cell cycle regulator family member A
Macaque
speedy/RINGO cell cycle regulator family member A
Mouse
Rat
Dog
speedy/RINGO cell cycle regulator family member A
Publication Statistics
PubMed Score 60.93
PubMed score by year
PubTator Score 24.74
PubTator score by year
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Related Publications
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PMID
Year
Title