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Tdark
SPDYC
Speedy protein C

Protein Summary
Description
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377185
  • ENSP00000366390
  • ENSG00000204710

Symbol
  • RINGOC
  • Ringo2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
cell line
0.52
tissue
0.42
chemical
0.41
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (7)
1 – 7 of 7
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.837
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.82
Data Source:  STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.6
Data Source:  STRINGDB
ARPP19
Tbio
Novelty:  0.03109958
Score:  0.539
Data Source:  STRINGDB
FCF1
Tdark
Novelty:  0.04202976
Score:  0.539
Data Source:  STRINGDB
FRRS1L
Tbio
Novelty:  0.00607449
Score:  0.535
Data Source:  STRINGDB
LARP7
Tchem
Novelty:  0.0304055
Score:  0.445
Data Source:  STRINGDB
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
87.8
high density lipoprotein cholesterol measurement
1
1
1
48.5
mean corpuscular hemoglobin concentration
1
1
1
40.7
BMI-adjusted hip circumference
1
2
2
34.7
mean corpuscular hemoglobin
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.8
high density lipoprotein cholesterol measurement
1
48.5
mean corpuscular hemoglobin concentration
1
40.7
BMI-adjusted hip circumference
2
34.7
mean corpuscular hemoglobin
1
33.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
speedy/RINGO cell cycle regulator family member C
VGNC:10232
451315
Macaque
speedy/RINGO cell cycle regulator family member C
721978
Dog
speedy/RINGO cell cycle regulator family member C
VGNC:52048
476026
Cow
speedy/RINGO cell cycle regulator family member C
VGNC:35199
513874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
speedy/RINGO cell cycle regulator family member C
Macaque
speedy/RINGO cell cycle regulator family member C
Dog
speedy/RINGO cell cycle regulator family member C
Cow
speedy/RINGO cell cycle regulator family member C
Publication Statistics
PubMed Score 2.24
PubMed score by year
PubTator Score 0.78
PubTator score by year