Tbio COLEC12 Collectin-12

Protein Summary

Description

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018]

Uniprot Accession IDs

• Q5KU26
• Q6P9F2
• Q8TCR2
• Q8WZA4
• Q9BY85
• Q9BYH7

Gene Name

• COLEC12

Ensembl ID

• ENST00000400256
• ENSP00000383115
• ENSG00000158270

Symbol

• CLP1
• NSR2
• SCARA4
• SRCL
• CLP1
• NSR2
• SRCL
• SCARA4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.9
cellular component	0.74
protein domain	0.73
tissue sample	0.73
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Collectin-12

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Structural Protein / Collectin-12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0