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Tbio
DGKK
Diacylglycerol kinase kappa

Protein Classes
Protein Summary
Description
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611977
  • ENSP00000477515
  • ENSG00000274588
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
protein domain
0.85
metabolite
0.83
gene perturbation
0.74
interacting protein
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.5
87
Familial hypospadias
1
1
0
2.6
73.7
testosterone measurement
2
2
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.5
87
Familial hypospadias
0
2.6
73.7
testosterone measurement
2
36.9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5KSL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
PLCB4
Tbio
Family:  Enzyme
Novelty:  0.01840915
Score:  0.708
Data Source:  STRINGDB
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.695
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.695
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.695
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.683
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.683
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.662
Data Source:  STRINGDB
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
Score:  0.662
Data Source:  STRINGDB
PLCB2
Tbio
Family:  Enzyme
Novelty:  0.00571285
Score:  0.662
Data Source:  STRINGDB
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.662
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.79

PubMed score by year
PubTator Score  9.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer