You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SAMD9
Sterile alpha motif domain-containing protein 9

Protein Summary
Description
May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379958
  • ENSP00000369292
  • ENSG00000205413
  • ENST00000620985
  • ENSP00000484636

Symbol
  • C7orf5
  • DRIF1
  • KIAA2004
  • OEF1
  • NFTC
  • OEF1
  • OEF2
  • DRIF1
  • C7orf5
  • MIRAGE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.61
cell line
0.59
small molecule perturbation
0.59
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 9
VGNC:4499
472443
Macaque
sterile alpha motif domain containing 9
702224
Horse
sterile alpha motif domain containing 9
VGNC:22681
100051216
Cow
sterile alpha motif domain containing 9
514205
Chicken
sterile alpha motif domain containing 9 like
CGNC:51287
420559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 9
Macaque
sterile alpha motif domain containing 9
Horse
sterile alpha motif domain containing 9
Cow
sterile alpha motif domain containing 9
Chicken
sterile alpha motif domain containing 9 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5K651-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (59)
1 – 10 of 59
HEPACAM2
Tbio
Novelty: 0.19192547
Score: 0.82
Data Source: STRINGDB
DDX60
Tbio
Family: Enzyme
Novelty: 0.09487565
Score: 0.815
Data Source: STRINGDB
SAMD9L
Tbio
Novelty: 0.03957268
Score: 0.8
Data Source: STRINGDB
IFI44
Tbio
Novelty: 0.02787222
Score: 0.798
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.783
Data Source: STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
Score: 0.754
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.752
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.743
Data Source: STRINGDB
VPS50
Tbio
Novelty: 0.17236696
Score: 0.735
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.731
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.39

PubMed score by year
PubTator Score  51.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer