Tbio EPHA10 Ephrin type-A receptor 10

Protein Summary

Description

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5JZY3
• A4FU89
• J3KPB5
• Q6NW42

Gene Name

• EPHA10

Ensembl ID

• ENST00000319637
• ENSP00000316395
• ENSG00000183317
• ENST00000373048
• ENSP00000362139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.98
microRNA	0.83
tissue sample	0.67
cellular component	0.6

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Eph Family / Ephrin Type-a Receptor 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0