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Tbio
Q5JWF2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are pater ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371100
  • ENSP00000360141
  • ENSG00000087460
  • ENST00000371102
  • ENSP00000360143

Symbol
  • GNAS1
  • AHO
  • GSA
  • GSP
  • POH
  • GPSA
  • NESP
  • SCG6
  • SgVI
  • GNAS1
  • PITA3
  • C20orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955.82   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955.82   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (380)
GNG2
Tbio
Novelty:  0.04807242
Score:  0.993
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.992
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.984
Data Source:  STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
Score:  0.979
Data Source:  STRINGDB
ADCY2
Tbio
Family:  Enzyme
Novelty:  0.01649836
Score:  0.978
Data Source:  STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.97
Data Source:  STRINGDB
ADRB2
Tclin
Family:  GPCR
Novelty:  0.00041821
Score:  0.969
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.969
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.968
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets (35)
Explore Nearest Tclin Targets
Pathways (83)
Aquaporin-mediated transport (R-HSA-445717)

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Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
G alpha (z) signalling events
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Class B/2 (Secretin family receptors)
G alpha (i) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
8
91.7
mean platelet volume
2
2
12
83.2
4
4
8
1.1
81.9
blood urea nitrogen measurement
3
3
12
73.8
creatinine measurement
2
2
8
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
91.7
mean platelet volume
12
83.2
8
1.1
81.9
blood urea nitrogen measurement
12
73.8
creatinine measurement
8
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 955.82
PubMed score by year
PubTator Score 1346.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title