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Tbio
HABP4
Intracellular hyaluronan-binding protein 4

Protein Summary
Description
RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375249
  • ENSP00000364398
  • ENSG00000130956
  • ENST00000375251
  • ENSP00000364400

Symbol
  • IHABP4
  • IHABP-4
  • Ki-1/57
  • SERBP1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.82
kinase perturbation
0.76
virus perturbation
0.68
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
88.8
intelligence
3
2
1
5.7
78.9
household income
1
1
1
32.9
self reported educational attainment
1
1
0
5.9
25.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
88.8
intelligence
1
5.7
78.9
household income
1
32.9
self reported educational attainment
0
5.9
25.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronan binding protein 4
VGNC:4756
742250
Mouse
MGI:1891713
56541
Rat
RGD:1306486
361196
Dog
hyaluronan binding protein 4
VGNC:41581
484133
Cow
hyaluronan binding protein 4
VGNC:29736
514807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronan binding protein 4
Mouse
Rat
Dog
hyaluronan binding protein 4
Cow
hyaluronan binding protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JVS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
RACK1
Tbio
Novelty: 0.00200617
Score: 0.828
Data Source: STRINGDB
RPL31
Tbio
Novelty: 0.03427872
Score: 0.775
Data Source: STRINGDB
RPS3
Tbio
Novelty: 0.003106
Score: 0.761
Data Source: STRINGDB
RPL32
Tbio
Novelty: 0.00279161
Score: 0.761
Data Source: STRINGDB
RPL38
Tbio
Novelty: 0.02694553
Score: 0.759
Data Source: STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
Score: 0.754
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.745
Data Source: STRINGDB
RPS16
Tbio
Novelty: 0.00261983
Score: 0.744
Data Source: STRINGDB
RPS5
Tbio
Novelty: 0.00513677
Score: 0.742
Data Source: STRINGDB
RPS9
Tbio
Novelty: 0.01329701
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.66

PubMed score by year
PubTator Score  13.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer