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Tdark
FRMPD3
FERM and PDZ domain-containing protein 3

Protein Summary
Description
This gene encodes a protein that contains a PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain at the N-terminus followed by a FERM domain. The encoded protein is involved in signal transduction. The PDZ domain is thought to function in protein-protein interactions, mainly by binding to specific C-terminal peptides of other proteins. The FERM domain is found in proteins that are localized to the plasma membrane and are associated with the cytoskeleton. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276185
  • ENSP00000276185
  • ENSG00000147234

Symbol
  • KIAA1817
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.6
tissue sample
0.55
protein complex
0.46
interacting protein
0.45


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 3
VGNC:12355
473721
Macaque
FERM and PDZ domain containing 3
702442
Dog
FERM and PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29382]
Cow
FERM and PDZ domain containing 3
VGNC:52781
517537
Opossum
FERM and PDZ domain containing 3
100028104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 3
Macaque
FERM and PDZ domain containing 3
Dog
FERM and PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29382]
Cow
FERM and PDZ domain containing 3
Opossum
FERM and PDZ domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JV73-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (108)
1 – 10 of 108
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.931
Data Source:  STRINGDB
RAP2B
Tbio
Family:  Enzyme
Novelty:  0.00347321
Score:  0.915
Data Source:  STRINGDB
RAP2C
Tbio
Family:  Enzyme
Novelty:  0.08572837
Score:  0.915
Data Source:  STRINGDB
RAB14
Tbio
Family:  Enzyme
Novelty:  0.01876172
Score:  0.909
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.907
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.905
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.902
Data Source:  STRINGDB
TRPM2
Tchem
Family:  IC
Novelty:  0.0076305
Score:  0.902
Data Source:  STRINGDB
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
Score:  0.902
Data Source:  STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.31

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer