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Tchem
KCNT1
Potassium channel subfamily T member 1

Protein Summary
Description
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative spl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371757
  • ENSP00000360822
  • ENSG00000107147
  • ENST00000487664
  • ENSP00000417851
  • ENST00000488444
  • ENSP00000419007
  • ENST00000628528
  • ENSP00000486374

Symbol
  • KIAA1422
  • ENFL5
  • SLACK
  • EIEE14
  • KCa4.1
  • Slo2.2
  • bA100C15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cellular component
0.55
transcription factor
0.55
ligand (chemical)
0.54
PubMedID
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (1)
1 – 1 of 1
Ca<sup>2+</sup>
no chemical structure image available
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
60
Protein-Protein Interactions (104)
1 – 10 of 104
SCN1A
Tclin
Family: IC
Novelty: 0.00109424
Score: 0.722
Data Source: STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00209684
Score: 0.721
Data Source: STRINGDB
KCNA2
Tclin
Family: IC
Novelty: 0.00164601
Score: 0.714
Data Source: STRINGDB
CHRNA2
Tchem
Family: IC
Novelty: 0.02542208
Score: 0.672
Data Source: STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.668
Data Source: STRINGDB
KCNA1
Tclin
Family: IC
Novelty: 0.00183322
Score: 0.667
Data Source: STRINGDB
TBC1D24
Tbio
Novelty: 0.0161631
Score: 0.666
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.665
Data Source: STRINGDB
CHRNB2
Tclin
Family: IC
Novelty: 0.01251655
Score: 0.644
Data Source: STRINGDB
SLC25A22
Tbio
Family: Transporter
Novelty: 0.05854569
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.39

PubMed score by year
PubTator Score  63.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer