Tchem KCNT1 Potassium channel subfamily T member 1

Protein Summary

Description

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q5JUK3
• B3KXF7
• B7ZVY4
• B9EGP2
• G5E9V0
• Q9P2C5

Gene Name

• KCNT1

Ensembl ID

• ENST00000371757
• ENSP00000360822
• ENSG00000107147
• ENST00000487664
• ENSP00000417851
• ENST00000488444
• ENSP00000419007
• ENST00000628528
• ENSP00000486374

Symbol

• KIAA1422
• ENFL5
• SLACK
• EIEE14
• KCa4.1
• Slo2.2
• bA100C15.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
cellular component	0.55
transcription factor	0.55
ligand (chemical)	0.54
PubMedID	0.54

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Kca4.1/kcnt1 Sub-subfamily / Potassium Channel Subfamily T Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.64   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.64   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3