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Tchem
KCNT1
Potassium channel subfamily T member 1

Protein Summary
Description
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative spl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371757
  • ENSP00000360822
  • ENSG00000107147
  • ENST00000487664
  • ENSP00000417851
  • ENST00000488444
  • ENSP00000419007
  • ENST00000628528
  • ENSP00000486374

Symbol
  • KIAA1422
  • ENFL5
  • SLACK
  • EIEE14
  • KCa4.1
  • Slo2.2
  • bA100C15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cellular component
0.55
transcription factor
0.55
ligand (chemical)
0.54
PubMedID
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (1)
1 – 1 of 1
Ca<sup>2+</sup>
no chemical structure image available
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
60
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium sodium-activated channel subfamily T member 1
721830
Mouse
MGI:1924627
227632
Rat
RGD:621106
60444
Dog
potassium sodium-activated channel subfamily T member 1
VGNC:42295
491258
Cow
potassium sodium-activated channel subfamily T member 1
VGNC:30494
529468
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium sodium-activated channel subfamily T member 1
Mouse
Rat
Dog
potassium sodium-activated channel subfamily T member 1
Cow
potassium sodium-activated channel subfamily T member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JUK3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (104)
1 – 10 of 104
SCN1A
Tclin
Family: IC
Novelty: 0.00109424
Score: 0.722
Data Source: STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00209684
Score: 0.721
Data Source: STRINGDB
KCNA2
Tclin
Family: IC
Novelty: 0.00164601
Score: 0.714
Data Source: STRINGDB
CHRNA2
Tchem
Family: IC
Novelty: 0.02542208
Score: 0.672
Data Source: STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.668
Data Source: STRINGDB
KCNA1
Tclin
Family: IC
Novelty: 0.00183322
Score: 0.667
Data Source: STRINGDB
TBC1D24
Tbio
Novelty: 0.0161631
Score: 0.666
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.665
Data Source: STRINGDB
CHRNB2
Tclin
Family: IC
Novelty: 0.01251655
Score: 0.644
Data Source: STRINGDB
SLC25A22
Tbio
Family: Transporter
Novelty: 0.05854569
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.39

PubMed score by year
PubTator Score  63.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer