Tbio IQSEC2 IQ motif and SEC7 domain-containing protein 2

Protein Summary

Description

Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q5JU85
• A0A1W2PQN3
• B3KT97
• C7SDG1
• O60275
• Q5JUX1

Gene Name

• IQSEC2

Ensembl ID

• ENST00000375365
• ENSP00000364514
• ENSG00000124313
• ENST00000396435
• ENSP00000379712
• ENST00000639161
• ENSP00000491796
• ENST00000642864
• ENSP00000495726

Symbol

• KIAA0522
• MRX1
• BRAG1
• MRX18
• MRX78
• IQ-ArfGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.78
cell type or tissue	0.76
protein domain	0.73
small molecule perturbation	0.62
cell line	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.9   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.9   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

APBA2

Tbio

Novelty:  0.01654185

p_int:  0.999992598

p_ni:  0.000007354

p_wrong:  4.8e-8

Score:  0.228

Data Source:  BioPlex,STRINGDB

ACVR2B

Tchem

Family:  Kinase

Novelty:  0.00555742

p_int:  0.999898948

p_ni:  0.000085721

p_wrong:  0.000015331

Data Source:  BioPlex

THBS3

Tbio

Novelty:  0.01915634

p_int:  0.999354666

p_ni:  0.000192214

p_wrong:  0.00045312

Score:  0.208

Data Source:  BioPlex,STRINGDB

ARF1

Tchem

Family:  Enzyme

Novelty:  0.00208554

Score:  0.973

Data Source:  STRINGDB

ARF3

Tbio

Family:  Enzyme

Novelty:  0.00336831

Score:  0.764

Data Source:  STRINGDB

DLG4

Tchem

Novelty:  0.00057285

Score:  0.764

Data Source:  STRINGDB

ARL17A

Tdark

Family:  Enzyme

Novelty:  0.37276049

Score:  0.739

Data Source:  STRINGDB

ARF6

Tbio

Family:  Enzyme

Novelty:  0.00278138

Score:  0.722

Data Source:  STRINGDB

KCNJ4

Tchem

Family:  IC

Novelty:  0.0093539

Score:  0.718

Data Source:  STRINGDB

ARHGEF9

Tbio

Novelty:  0.01577146

Score:  0.688

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (2)

Processes (4)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (3)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	1	1	1		42.3
monocyte percentage of leukocytes	EFO_0007989	1	1	1		30.2
testosterone measurement	EFO_0004908	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	1		42.3
monocyte percentage of leukocytes	EFO_0007989	1		30.2
testosterone measurement	EFO_0004908	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Mental retardation
Methylation
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
monocyte percentage of leukocytes
neutrophil count
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	IQ motif and Sec7 domain 2		702562
Mouse	IQ motif and Sec7 domain 2	MGI:3528396	245666
Dog	IQ motif and Sec7 domain 2	VGNC:42084	491895
Horse	IQ motif and Sec7 domain 2 [Source:HGNC Symbol;Acc:HGNC:29059]
Cow	IQ motif and Sec7 domain 2	VGNC:30262	517311

Species	Name	OMA	EggNOG	Inparanoid
Macaque	IQ motif and Sec7 domain 2
Mouse	IQ motif and Sec7 domain 2
Dog	IQ motif and Sec7 domain 2
Horse	IQ motif and Sec7 domain 2 [Source:HGNC Symbol;Acc:HGNC:29059]
Cow	IQ motif and Sec7 domain 2

Publication Statistics

PubMed Score 67.90

PubMed score by year

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PubTator Score 27.99

PubTator score by year

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Related Publications

Text Mined References (33)

GeneRif Annotations (13)

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0 of 0

PMID	Year	Title