Tbio TCTE1 Dynein regulatory complex subunit 5

Protein Summary

Description

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.

Uniprot Accession IDs

• Q5JU00
• B4DX59
• Q8IYS6

Gene Name

• TCTE1

Ensembl ID

• ENST00000371505
• ENSP00000360560
• ENSG00000146221

Symbol

• DRC5
• DRC5
• D6S46
• FAP155

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.68
cell type or tissue	0.6
cell line	0.55
tissue	0.55
PubMedID	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.15   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.15   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0