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Tbio
TCTE1
Dynein regulatory complex subunit 5

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371505
  • ENSP00000360560
  • ENSG00000146221

Symbol
  • DRC5
  • DRC5
  • D6S46
  • FAP155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
cell type or tissue
0.6
cell line
0.55
tissue
0.55
PubMedID
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
85
mean corpuscular volume
1
2
2
83.5
4
2
3
1.2
76.8
monocyte percentage of leukocytes
2
1
2
70.5
monocyte count
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
85
mean corpuscular volume
2
83.5
3
1.2
76.8
monocyte percentage of leukocytes
2
70.5
monocyte count
1
59.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
t-complex-associated-testis-expressed 1
462732
Macaque
t-complex-associated-testis-expressed 1
702738
Mouse
MGI:98640
21645
Rat
RGD:1305744
316242
Dog
t-complex-associated-testis-expressed 1
VGNC:47211
609664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
t-complex-associated-testis-expressed 1
Macaque
t-complex-associated-testis-expressed 1
Mouse
Rat
Dog
t-complex-associated-testis-expressed 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JU00-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (75)
1 – 10 of 75
TCP10
Tbio
Novelty:  0.06680788
Score:  0.718
Data Source:  STRINGDB
IQCA1
Tdark
Novelty:  0.33986781
Score:  0.717
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.711
Data Source:  STRINGDB
MED6
Tbio
Family:  Enzyme
Novelty:  0.05215086
Score:  0.706
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
DRC7
Tdark
Novelty:  0.40606004
Score:  0.68
Data Source:  STRINGDB
GAS8
Tbio
Novelty:  0.03540885
Score:  0.677
Data Source:  STRINGDB
CCDC65
Tdark
Novelty:  0.05107666
Score:  0.676
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.21

PubMed score by year
PubTator Score  4.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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