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Tbio
AARS2
Alanine--tRNA ligase, mitochondrial

Protein Summary
Description
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244571
  • ENSP00000244571
  • ENSG00000124608

Symbol
  • AARSL
  • KIAA1270
  • AARSL
  • LKENP
  • COXPD8
  • MTALARS
  • MT-ALARS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
transcription factor binding site profile
0.93
histone modification site profile
0.79
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999859895
p_ni:  0.000140105
Data Source:  BioPlex
SUCLG1
Tbio
Family:  Enzyme
Novelty:  0.01113643
p_int:  0.99855023
p_ni:  0.00144977
Score:  0.282
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.997757087
p_ni:  0.002242913
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.990535654
p_ni:  0.009464346
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.988131245
p_ni:  0.011868755
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.960402379
p_ni:  0.039597621
Score:  0.239
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.950018782
p_ni:  0.049981218
Score:  0.237
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.865515721
p_ni:  0.134484279
Data Source:  BioPlex
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
p_int:  0.860013062
p_ni:  0.139986938
Data Source:  BioPlex
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.842909027
p_ni:  0.157090973
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
85
mean corpuscular volume
1
2
2
83.5
4
2
3
1.2
76.8
monocyte percentage of leukocytes
2
1
2
70.5
monocyte count
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
85
mean corpuscular volume
2
83.5
3
1.2
76.8
monocyte percentage of leukocytes
2
70.5
monocyte count
1
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alanyl-tRNA synthetase 2, mitochondrial
VGNC:11025
462733
Macaque
alanyl-tRNA synthetase 2, mitochondrial
702626
Mouse
MGI:2681839
224805
Rat
RGD:1310617
301254
Dog
alanyl-tRNA synthetase 2, mitochondrial
VGNC:37416
474920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alanyl-tRNA synthetase 2, mitochondrial
Macaque
alanyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
alanyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 76.56
PubMed score by year
PubTator Score 15.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title