You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CEP78
Centrosomal protein of 78 kDa

Protein Summary
Description
May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451). This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376597
  • ENSP00000365782
  • ENSG00000148019
  • ENST00000415759
  • ENSP00000399286
  • ENST00000424347
  • ENSP00000411284
  • ENST00000642669
  • ENSP00000495681
  • ENST00000643273
  • ENSP00000496423

Symbol
  • C9orf81
  • IP63
  • CRDHL
  • C9orf81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.61
transcription factor perturbation
0.61
transcription factor
0.59
cell type or tissue
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 78
VGNC:4658
464541
Macaque
centrosomal protein of 78 kDa
706167
Mouse
MGI:1924386
208518
Rat
RGD:620464
60347
Dog
centrosomal protein 78
VGNC:39138
607243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 78
Macaque
centrosomal protein of 78 kDa
Mouse
Rat
Dog
centrosomal protein 78
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JTW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (147)
1 – 10 of 147
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.993985682
p_ni: 0.006014317
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.978221694
p_ni: 0.021778306
Data Source: BioPlex
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.875397261
p_ni: 0.124602739
Data Source: BioPlex
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.8393301
p_ni: 0.1606699
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.795425358
p_ni: 0.204574642
Score: 0.181
Data Source: BioPlex,STRINGDB
CEP76
Tdark
Novelty: 0.3880387
Score: 0.966
Data Source: STRINGDB
CEP250
Tbio
Novelty: 0.08014712
Score: 0.958
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.954
Data Source: STRINGDB
SCLT1
Tbio
Novelty: 0.10969171
Score: 0.953
Data Source: STRINGDB
CEP63
Tbio
Novelty: 0.08869992
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.42

PubMed score by year
PubTator Score  6.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer