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Tbio
COA6
Cytochrome c oxidase assembly factor 6 homolog

Protein Summary
Description
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366612
  • ENSP00000355571
  • ENSG00000168275
  • ENST00000366613
  • ENSP00000355572
  • ENST00000366615
  • ENSP00000355574
  • ENST00000619305
  • ENSP00000479686

Symbol
  • C1orf31
  • C1orf31
  • CEMCOX4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.79
transcription factor binding site profile
0.67
interacting protein
0.65
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
CYC1
Tchem
Novelty:  0.01369865
Score:  0.99
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.963
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.963
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.961
Data Source:  STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
Score:  0.956
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.951
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.946
Data Source:  STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
Score:  0.943
Data Source:  STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
Score:  0.935
Data Source:  STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Mitochondrial protein import (R-HSA-1268020)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to anticonvulsant
1
1
0
4.5
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to anticonvulsant
0
4.5
0.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
uncharacterized LOC718775
718775
Mouse
MGI:1915142
67892
Dog
cytochrome c oxidase assembly factor 6
VGNC:39444
607627
Horse
cytochrome c oxidase assembly factor 6
VGNC:16709
100629695
Pig
cytochrome c oxidase assembly factor 6 homolog
100512926
Species
Name
OMA
EggNOG
Inparanoid
Macaque
uncharacterized LOC718775
Mouse
Dog
cytochrome c oxidase assembly factor 6
Horse
cytochrome c oxidase assembly factor 6
Pig
cytochrome c oxidase assembly factor 6 homolog
Publication Statistics
PubMed Score 13.69
PubMed score by year
PubTator Score 5.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title