Tbio COA6 Cytochrome c oxidase assembly factor 6 homolog

Protein Summary

Description

Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q5JTJ3
• Q5JTJ2
• Q5JTJ4
• Q8TA88

Gene Name

• COA6

Ensembl ID

• ENST00000366612
• ENSP00000355571
• ENSG00000168275
• ENST00000366613
• ENSP00000355572
• ENST00000366615
• ENSP00000355574
• ENST00000619305
• ENSP00000479686

Symbol

• C1orf31
• C1orf31
• CEMCOX4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
molecular function	0.79
transcription factor binding site profile	0.67
interacting protein	0.65
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0