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Tbio
AMER1
APC membrane recruitment protein 1

Protein Summary
Description
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330258
  • ENSP00000329117
  • ENSG00000184675
  • ENST00000374869
  • ENSP00000364003

Symbol
  • FAM123B
  • WTX
  • WTX
  • OSCS
  • FAM123B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
pathway
0.85
microRNA
0.7
cell line
0.6
phenotype
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.08   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.08   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999998133
p_ni:  0.000001867
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999924463
p_ni:  0.000075526
p_wrong:  1.2e-8
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999816452
p_ni:  0.000183548
Data Source:  BioPlex
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.99978481
p_ni:  0.000201507
p_wrong:  0.000013684
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.999759589
p_ni:  0.000240411
Score:  0.583
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999710677
p_ni:  0.000289322
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.99873739
p_ni:  0.001262608
p_wrong:  2e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.998209205
p_ni:  0.0014889
p_wrong:  0.000301895
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.996747379
p_ni:  0.003249803
p_wrong:  0.000002818
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.996476163
p_ni:  0.003523836
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (96)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

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Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Beta-catenin phosphorylation cascade
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Beta-catenin phosphorylation cascade
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
APC membrane recruitment protein 1
707700
Mouse
MGI:1919595
72345
Rat
RGD:1560322
501584
Dog
APC membrane recruitment protein 1
VGNC:37828
606822
Horse
APC membrane recruitment protein 1
VGNC:15274
100054310
Species
Name
OMA
EggNOG
Inparanoid
Macaque
APC membrane recruitment protein 1
Mouse
Rat
Dog
APC membrane recruitment protein 1
Horse
APC membrane recruitment protein 1
Publication Statistics
PubMed Score 114.08
PubMed score by year
PubTator Score 59.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title