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Tbio
AMER1
APC membrane recruitment protein 1

Protein Summary
Description
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330258
  • ENSP00000329117
  • ENSG00000184675
  • ENST00000374869
  • ENSP00000364003

Symbol
  • FAM123B
  • WTX
  • WTX
  • OSCS
  • FAM123B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
pathway
0.85
microRNA
0.7
cell line
0.6
phenotype
0.57


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.11   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.11   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
APC membrane recruitment protein 1
707700
Mouse
MGI:1919595
72345
Rat
RGD:1560322
501584
Dog
APC membrane recruitment protein 1
VGNC:37828
606822
Horse
APC membrane recruitment protein 1
VGNC:15274
100054310
Species
Name
OMA
EggNOG
Inparanoid
Macaque
APC membrane recruitment protein 1
Mouse
Rat
Dog
APC membrane recruitment protein 1
Horse
APC membrane recruitment protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5JTC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (96)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Beta-catenin phosphorylation cascade
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Beta-catenin phosphorylation cascade
Protein-Protein Interactions (143)
1 – 10 of 143
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999998133
p_ni: 0.000001867
Data Source: BioPlex
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.999924463
p_ni: 0.000075526
p_wrong: 1.2e-8
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999816452
p_ni: 0.000183548
Data Source: BioPlex
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.99978481
p_ni: 0.000201507
p_wrong: 0.000013684
Data Source: BioPlex
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999759589
p_ni: 0.000240411
Score: 0.583
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999710677
p_ni: 0.000289322
p_wrong: 1e-9
Score: 0.975
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.99873739
p_ni: 0.001262608
p_wrong: 2e-9
Score: 0.195
Data Source: BioPlex,STRINGDB
NOG
Tbio
Novelty: 0.0010373
p_int: 0.998209205
p_ni: 0.0014889
p_wrong: 0.000301895
Data Source: BioPlex
TSPYL1
Tbio
Novelty: 0.06381144
p_int: 0.996747379
p_ni: 0.003249803
p_wrong: 0.000002818
Data Source: BioPlex
TSPYL6
Tdark
Novelty: 0.68478376
p_int: 0.996476163
p_ni: 0.003523836
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  111.11

PubMed score by year
PubTator Score  59.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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