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Tdark
RAB41
Ras-related protein Rab-41

Protein Summary
Description
Required for normal Golgi ribbon organization and ER-to-Golgi trafficking. This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276066
  • ENSP00000276066
  • ENSG00000147127
  • ENST00000374473
  • ENSP00000363597
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
tissue
0.63
protein domain
0.58
tissue sample
0.47
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (107)
1 – 10 of 107
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.999998348
p_ni:  0.000001482
p_wrong:  1.7e-7
Score:  0.916
Data Source:  BioPlex,STRINGDB
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
p_int:  0.950270687
p_ni:  0.049729313
Score:  0.633
Data Source:  BioPlex,STRINGDB
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.861182098
p_ni:  0.138817901
p_wrong:  1e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
Score:  0.938
Data Source:  STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.938
Data Source:  STRINGDB
COG4
Tbio
Novelty:  0.03809668
Score:  0.937
Data Source:  STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.934
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.934
Data Source:  STRINGDB
RAB1B
Tbio
Family:  Enzyme
Novelty:  0.02156819
Score:  0.933
Data Source:  STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
Score:  0.933
Data Source:  STRINGDB
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB41, member RAS oncogene family
VGNC:7629
745949
Macaque
RAB41, member RAS oncogene family
695349
S.cerevisiae
S000004252
850966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB41, member RAS oncogene family
Macaque
RAB41, member RAS oncogene family
S.cerevisiae
Publication Statistics
PubTator Score 2.15
PubTator score by year