You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FGD3
FYVE, RhoGEF and PH domain-containing protein 3

Protein Summary
Description
Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337352
  • ENSP00000336914
  • ENSG00000127084
  • ENST00000375482
  • ENSP00000364631
  • ENST00000416701
  • ENSP00000413833
  • ENST00000467786
  • ENSP00000432310
  • ENST00000468206
  • ENSP00000496819

Symbol
  • ZFYVE5
  • ZFYVE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.76
interacting protein
0.71
histone modification site profile
0.63
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0