You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RALGPS1
Ras-specific guanine nucleotide-releasing factor RalGPS1

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259351
  • ENSP00000259351
  • ENSG00000136828
  • ENST00000373434
  • ENSP00000362533
  • ENST00000373436
  • ENSP00000362535
  • ENST00000394011
  • ENSP00000377579
  • ENST00000394022
  • ENSP00000377590
  • ENST00000424082
  • ENSP00000415630

Symbol
  • KIAA0351
  • RALGEF2
  • RALGEF2
  • RALGPS1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.97
virus perturbation
0.88
kinase perturbation
0.76
transcription factor
0.61
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
5
94.7
alcohol consumption measurement
3
2
3
73.3
1
1
0
1.1
70.7
body fat distribution
2
1
4
47.3
mosaic loss of chromosome Y measurement
1
1
1
44.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
94.7
alcohol consumption measurement
3
73.3
0
1.1
70.7
body fat distribution
4
47.3
mosaic loss of chromosome Y measurement
1
44.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (33)
1 – 10 of 33
RALA
Tbio
Family: Enzyme
Novelty: 0.00257914
Score: 0.764
Data Source: STRINGDB
KYAT1
Tbio
Family: Enzyme
Novelty: 0.01232903
Score: 0.713
Data Source: STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.682
Data Source: STRINGDB
RALB
Tbio
Family: Enzyme
Novelty: 0.01605746
Score: 0.671
Data Source: STRINGDB
GARNL3
Tdark
Family: Enzyme
Novelty: 0.81910134
Score: 0.659
Data Source: STRINGDB
RABGEF1
Tbio
Novelty: 0.02830695
Score: 0.647
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.614
Data Source: STRINGDB
TSPEAR
Tbio
Novelty: 0.15908638
Score: 0.582
Data Source: STRINGDB
VWA3A
Tdark
Novelty: 1.18678257
Score: 0.563
Data Source: STRINGDB
KYAT3
Tbio
Family: Enzyme
Novelty: 0.05845124
Score: 0.541
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.41

PubMed score by year
PubTator Score  2.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: