Tchem PITRM1 Presequence protease, mitochondrial

Protein Summary

Description

Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q5JRX3
• B3KMJ6
• B4E0J8
• C9JSL2
• E7ES23
• O95204
• Q2M2G6
• Q4VBR1
• Q5JRW7
• Q7L5Z7
• Q9BSI6
• Q9BVJ5
• Q9UPP8
• hPreP

Gene Name

• PITRM1

Ensembl ID

• ENST00000224949
• ENSP00000224949
• ENSG00000107959
• ENST00000380989
• ENSP00000370377
• ENST00000451104
• ENSP00000401201

Symbol

• KIAA1104
• MP1
• MP1
• PreP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.81
transcription factor binding site profile	0.74
protein domain	0.73
tissue sample	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Presequence Protease, Mitochondrial

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Presequence Protease, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.18   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.18   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0