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Tbio
MIA3
Transport and Golgi organization protein 1 homolog

Protein Summary
Description
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340535
  • ENSP00000345866
  • ENSG00000154305
  • ENST00000344507
  • ENSP00000341348
  • ENST00000344922
  • ENSP00000340900

Symbol
  • KIAA0268
  • TANGO
  • ARNT
  • D320
  • TANGO
  • TANGO1
  • UNQ6077
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cellular component
0.74
transcription factor perturbation
0.74
cell line
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.78   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.78   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
96.9
2
2
0
1.1
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
96.9
0
1.1
78.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (188)
1 – 10 of 188
CTAGE5
Tbio
Novelty: 0.04516631
p_int: 0.999999716
p_ni: 2.84e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
SIGLEC12
Tbio
Novelty: 0.00914453
p_int: 0.999997035
p_ni: 0.000002942
p_wrong: 2.3e-8
Score: 0.237
Data Source: BioPlex,STRINGDB
CTAGE6
Tdark
Novelty: 52
p_int: 0.999923511
p_ni: 0.000076489
Score: 0.837
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999705987
p_ni: 0.000294013
Data Source: BioPlex
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.998254814
p_ni: 0.001745186
Data Source: BioPlex
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.991000619
p_ni: 0.008999381
Data Source: BioPlex
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.990768296
p_ni: 0.009231704
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.990404072
p_ni: 0.009595928
Data Source: BioPlex
MTMR7
Tbio
Family: Enzyme
Novelty: 0.1707096
p_int: 0.990209726
p_ni: 0.009790274
Score: 0.165
Data Source: BioPlex,STRINGDB
HAO2
Tchem
Family: Enzyme
Novelty: 0.03029536
p_int: 0.984851936
p_ni: 0.015148064
Data Source: BioPlex
Publication Statistics
PubMed Score  41.78

PubMed score by year
PubTator Score  42.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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