Tbio MIA3 Transport and Golgi organization protein 1 homolog

Protein Summary

Description

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of CTAGE5 and PREB/SEC12 to ERES (PubMed:28442536).

Uniprot Accession IDs

• Q5JRA6
• A8K2S0
• A8MT05
• A8MT13
• B7Z430
• Q14083
• Q3S4X3
• Q5JRA5
• Q5JRB0
• Q5JRB1
• Q5JRB2
• Q6UVY8
• Q86Y60
• Q8N8M5
• Q92580
• TANGO1

Gene Name

• MIA3

Ensembl ID

• ENST00000340535
• ENSP00000345866
• ENSG00000154305
• ENST00000344507
• ENSP00000341348
• ENST00000344922
• ENSP00000340900

Symbol

• KIAA0268
• TANGO
• ARNT
• D320
• TANGO
• TANGO1
• UNQ6077

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
cellular component	0.74
transcription factor perturbation	0.74
cell line	0.73
tissue sample	0.72

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Transport And Golgi Organization Protein 1 Homolog

DTO Classes

Protein / Signaling / Growth Factor / Transport And Golgi Organization Protein 1 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.53   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.53   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0