Tbio MTUS2 Microtubule-associated tumor suppressor candidate 2

Protein Summary

Description

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Uniprot Accession IDs

• Q5JR59
• A7E292
• B4DF81
• O94872
• Q08E97
• Q5JQR3
• Q8N5E2

Gene Name

• MTUS2

Ensembl ID

• ENST00000380808
• ENSP00000370186
• ENSG00000132938
• ENST00000542829
• ENSP00000445403

Symbol

• CAZIP
• KIAA0774
• TIP150
• ICIS
• CAZIP
• TIP150
• KIAA0774

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
cell type or tissue	0.74
phenotype	0.68
tissue sample	0.68
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2008.24   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2008.24   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0