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Tdark
OR2B11
Olfactory receptor 2B11

Protein Summary
Description
Odorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318749
  • ENSP00000325682
  • ENSG00000177535
  • ENST00000641149
  • ENSP00000492892
  • ENST00000641527
  • ENSP00000493421
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
cell line
0.61
tissue
0.46
protein domain
0.41
phenotype
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
3
97
BMI-adjusted waist circumference
1
1
1
6.8
monocyte count
1
1
1
2.5
lymphocyte count
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
97
BMI-adjusted waist circumference
1
6.8
monocyte count
1
2.5
lymphocyte count
1
2.5
Pathways (6)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (36)
1 – 10 of 36
REEP6
Tbio
Novelty: 0.10645981
Score: 0.9
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.9
Data Source: STRINGDB
RTP4
Tbio
Novelty: 0.05959975
Score: 0.9
Data Source: STRINGDB
REEP4
Tbio
Novelty: 0.37950931
Score: 0.9
Data Source: STRINGDB
RTP5
Tdark
Novelty: 0.21798595
Score: 0.9
Data Source: STRINGDB
REEP1
Tbio
Novelty: 0.02280713
Score: 0.9
Data Source: STRINGDB
REEP5
Tbio
Novelty: 0.00160455
Score: 0.9
Data Source: STRINGDB
RTP2
Tbio
Novelty: 0.05972678
Score: 0.9
Data Source: STRINGDB
REEP3
Tbio
Novelty: 0.19673119
Score: 0.9
Data Source: STRINGDB
RTP1
Tbio
Novelty: 0.0278378
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.74

PubMed score by year
PubTator Score  0.83

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer