Protein Summary
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
- ENST00000376314
- ENSP00000417128
- ENSG00000204548
- DEFB21
- DEFB21
- ESC42RELC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.36 | ||
biological term | 0.33 | ||
cell line | 0.33 | ||
tissue | 0.33 | ||
pathway | 0.32 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.27 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.27 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
TCTEX1D2
Novelty: 0.15075459
p_int: 0.999152242
p_ni: 0.000834781
p_wrong: 0.000012977
Score: 0.189
Data Source: BioPlex,STRINGDB
VWDE
Novelty: 0.37298162
p_int: 0.991131441
p_ni: 0.008858829
p_wrong: 0.00000973
Score: 0.243
Data Source: BioPlex,STRINGDB
CPS1
Family: Enzyme
Novelty: 0.00917469
p_int: 0.989052929
p_ni: 0.010947071
Data Source: BioPlex
COL6A2
Novelty: 0.01275082
p_int: 0.986183443
p_ni: 0.013816555
p_wrong: 2e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
TMEM67
Novelty: 0.02573267
p_int: 0.96363693
p_ni: 0.036353814
p_wrong: 0.000009257
Score: 0.185
Data Source: BioPlex,STRINGDB
NHLRC3
Novelty: 1.23813202
p_int: 0.807390897
p_ni: 0.191487706
p_wrong: 0.001121397
Score: 0.309
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00557848
p_int: 0.768138093
p_ni: 0.21864963
p_wrong: 0.013212277
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Beta defensins | ||||
Reactome | Defensins | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antimicrobial peptides | ||||
Beta defensins | ||||
Defensins | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 36.9 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 32.6 | |||||
smoking behavior | 1 | 1 | 1 | 24.5 | |||||
smoking initiation | 1 | 1 | 1 | 14.2 | |||||
smoking status measurement | 1 | 1 | 1 | 12.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 36.9 | |||||
alkaline phosphatase measurement | 1 | 32.6 | |||||
smoking behavior | 1 | 24.5 | |||||
smoking initiation | 1 | 14.2 | |||||
smoking status measurement | 1 | 12.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | defensin beta 121 | VGNC:6090 | 746082 | |||||
Macaque | defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | defensin beta 121 | |||||
Macaque | defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101] | |||||
Publication Statistics
PubMed Score 0.27
PubMed score by year
PubTator Score 0.25
PubTator score by year
Related Publications
Text Mined References (5)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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