Protein Summary
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
- ENST00000376314
- ENSP00000417128
- ENSG00000204548
- DEFB21
- DEFB21
- ESC42RELC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.36 | ||
biological term | 0.33 | ||
cell line | 0.33 | ||
tissue | 0.33 | ||
pathway | 0.32 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.27 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.27 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
TCTEX1D2
Novelty: 0.15075459
p_int: 0.999152242
p_ni: 0.000834781
p_wrong: 0.000012977
Score: 0.189
Data Source: BioPlex,STRINGDB
VWDE
Novelty: 0.37298162
p_int: 0.991131441
p_ni: 0.008858829
p_wrong: 0.00000973
Score: 0.243
Data Source: BioPlex,STRINGDB
CPS1
Family: Enzyme
Novelty: 0.00917469
p_int: 0.989052929
p_ni: 0.010947071
Data Source: BioPlex
COL6A2
Novelty: 0.01275082
p_int: 0.986183443
p_ni: 0.013816555
p_wrong: 2e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
TMEM67
Novelty: 0.02573267
p_int: 0.96363693
p_ni: 0.036353814
p_wrong: 0.000009257
Score: 0.185
Data Source: BioPlex,STRINGDB
NHLRC3
Novelty: 1.23813202
p_int: 0.807390897
p_ni: 0.191487706
p_wrong: 0.001121397
Score: 0.309
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00557848
p_int: 0.768138093
p_ni: 0.21864963
p_wrong: 0.013212277
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Beta defensins | ||||
Reactome | Defensins | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antimicrobial peptides | ||||
Beta defensins | ||||
Defensins | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 36.9 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 32.6 | |||||
smoking behavior | 1 | 1 | 1 | 24.5 | |||||
smoking initiation | 1 | 1 | 1 | 14.2 | |||||
smoking status measurement | 1 | 1 | 1 | 12.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 36.9 | |||||
alkaline phosphatase measurement | 1 | 32.6 | |||||
smoking behavior | 1 | 24.5 | |||||
smoking initiation | 1 | 14.2 | |||||
smoking status measurement | 1 | 12.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | defensin beta 121 | VGNC:6090 | 746082 | |||||
Macaque | defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | defensin beta 121 | |||||
Macaque | defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101] | |||||
Publication Statistics
PubMed Score 0.27
PubMed score by year
PubTator Score 0.25
PubTator score by year
Related Publications
Text Mined References (5)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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