Tdark DEFB121 Beta-defensin 121

Protein Summary

Description

Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q5J5C9
• A1L4N1

Gene Name

• DEFB121

Ensembl ID

• ENST00000376314
• ENSP00000417128
• ENSG00000204548

Symbol

• DEFB21
• DEFB21
• ESC42RELC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.36
biological term	0.33
cell line	0.33
tissue	0.33
pathway	0.32

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0