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Tdark
DDX60L
Probable ATP-dependent RNA helicase DDX60-like

Protein Summary
Description
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260184
  • ENSP00000260184
  • ENSG00000181381
  • ENST00000505890
  • ENSP00000422202
  • ENST00000511577
  • ENSP00000422423
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.93
cell type or tissue
0.81
microRNA
0.81
tissue sample
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
40.7
IGF-1 measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
40.7
IGF-1 measurement
1
33.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DExD/H-box 60 like
VGNC:48898
461595
Macaque
DExD/H-box 60 like
693749
Horse
DExD/H-box 60 like
VGNC:49403
100067542
Platypus
probable ATP-dependent RNA helicase DDX60
100077465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DExD/H-box 60 like
Macaque
DExD/H-box 60 like
Horse
DExD/H-box 60 like
Platypus
probable ATP-dependent RNA helicase DDX60
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5H9U9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
Score:  0.679
Data Source:  STRINGDB
YTHDC2
Tbio
Family:  Enzyme
Novelty:  0.05211009
Score:  0.655
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.648
Data Source:  STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.64
Data Source:  STRINGDB
FBH1
Tbio
Family:  Enzyme
Novelty:  0.04243458
Score:  0.638
Data Source:  STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
Score:  0.622
Data Source:  STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
Score:  0.611
Data Source:  STRINGDB
DDX60
Tbio
Family:  Enzyme
Novelty:  0.09487565
Score:  0.603
Data Source:  STRINGDB
WDR3
Tbio
Novelty:  0.15410886
Score:  0.591
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.585
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.92

PubMed score by year
PubTator Score  0.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer