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Tbio
PPP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

Protein Summary
Description
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265636
  • ENSP00000265636
  • ENSG00000110075
  • ENST00000393800
  • ENSP00000377389
  • ENST00000393801
  • ENSP00000377390
  • ENST00000524845
  • ENSP00000431415
  • ENST00000524904
  • ENSP00000433058
  • ENST00000529710
  • ENSP00000437329

Symbol
  • C11orf23
  • KIAA1558
  • PP6R3
  • SAPL
  • SAPS3
  • SAPL
  • PP6R3
  • SAPLa
  • SAPS3
  • SAP190
  • C11orf23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
gene perturbation
0.92
transcription factor binding site profile
0.9
kinase perturbation
0.88
transcription factor
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
4
4
7
98.4
appendicular lean mass
2
2
3
97.1
heel bone mineral density
1
1
1
92.7
self reported educational attainment
1
1
1
76.5
mean corpuscular hemoglobin concentration
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
7
98.4
appendicular lean mass
3
97.1
heel bone mineral density
1
92.7
self reported educational attainment
1
76.5
mean corpuscular hemoglobin concentration
1
75.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 6 regulatory subunit 3
VGNC:3061
747492
Macaque
protein phosphatase 6 regulatory subunit 3
710120
Mouse
MGI:1921807
52036
Rat
RGD:1307145
309144
Dog
protein phosphatase 6 regulatory subunit 3
VGNC:44927
483688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 6 regulatory subunit 3
Macaque
protein phosphatase 6 regulatory subunit 3
Mouse
Rat
Dog
protein phosphatase 6 regulatory subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5H9R7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
MGI
Protein-Protein Interactions (61)
1 – 10 of 61
ANKRD44
Tdark
Family: Enzyme
Novelty: 0.38360979
p_int: 0.967331127
p_ni: 0.032668873
Score: 0.911
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.900172023
p_ni: 0.099827977
Score: 0.319
Data Source: BioPlex,STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.775365977
p_ni: 0.224634023
Score: 0.742
Data Source: BioPlex,STRINGDB
PPP6C
Tbio
Family: Enzyme
Novelty: 0.00230341
Score: 0.997
Data Source: Reactome,STRINGDB
ANKRD28
Tbio
Family: Enzyme
Novelty: 0.10895759
Score: 0.967
Data Source: Reactome,STRINGDB
SEC24B
Tbio
Novelty: 0.01031644
Score: 0.911
Data Source: STRINGDB
SEC24D
Tbio
Novelty: 0.04795527
Score: 0.905
Data Source: STRINGDB
SEC24C
Tbio
Novelty: 0.05842956
Score: 0.902
Data Source: STRINGDB
SEC24A
Tbio
Novelty: 0.07724534
Score: 0.902
Data Source: STRINGDB
EIF4A3
Tbio
Novelty: 0.00981496
Score: 0.868
Data Source: STRINGDB
Publication Statistics
PubMed Score  244.52

PubMed score by year
PubTator Score  98.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer