Tbio PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3

Protein Summary

Description

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q5H9R7
• Q3B7I1
• Q3I4Y0
• Q3KR35
• Q68CR3
• Q7L4R8
• Q8N3B2
• Q96MB2
• Q9H2K5
• Q9H2K6
• Q9HCL4
• Q9NUY3

Gene Name

• PPP6R3

Ensembl ID

• ENST00000265636
• ENSP00000265636
• ENSG00000110075
• ENST00000393800
• ENSP00000377389
• ENST00000393801
• ENSP00000377390
• ENST00000524845
• ENSP00000431415
• ENST00000524904
• ENSP00000433058
• ENST00000529710
• ENSP00000437329

Symbol

• C11orf23
• KIAA1558
• PP6R3
• SAPL
• SAPS3
• SAPL
• PP6R3
• SAPLa
• SAPS3
• SAP190
• C11orf23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
gene perturbation	0.92
transcription factor binding site profile	0.9
kinase perturbation	0.88
transcription factor	0.86

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Serine/threonine-protein Phosphatase 6 Regulatory Subunit 3

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Serine/threonine-protein Phosphatase 6 Regulatory Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.47   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.47   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0