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Tbio
HERC4
Probable E3 ubiquitin-protein ligase HERC4

Protein Summary
Description
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277817
  • ENSP00000277817
  • ENSG00000148634
  • ENST00000373700
  • ENSP00000362804
  • ENST00000395198
  • ENSP00000378624
  • ENST00000412272
  • ENSP00000416504
  • ENST00000473533
  • ENSP00000423671
  • ENST00000492996
  • ENSP00000422383

Symbol
  • KIAA1593
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor perturbation
0.88
disease perturbation
0.74
transcription factor binding site profile
0.74
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
89.4
sex hormone-binding globulin measurement
2
1
2
43.1
body mass index
1
1
1
20
pulse pressure measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
89.4
sex hormone-binding globulin measurement
2
43.1
body mass index
1
20
pulse pressure measurement
1
4
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 4
695571
Mouse
MGI:1914595
67345
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 4
Mouse
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5GLZ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (287)
1 – 10 of 287
C1orf94
Tdark
Novelty: 23
p_int: 0.999990639
p_ni: 0.000009361
Score: 0.188
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.999711822
p_ni: 0.000258926
p_wrong: 0.000029252
Data Source: BioPlex
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.999341393
p_ni: 0.000658607
Data Source: BioPlex
FDXACB1
Tdark
Novelty: 67
p_int: 0.996861029
p_ni: 0.003116098
p_wrong: 0.000022873
Score: 0.34
Data Source: BioPlex,STRINGDB
MOCS3
Tbio
Family: Enzyme
Novelty: 0.039209
p_int: 0.994583331
p_ni: 0.005385064
p_wrong: 0.000031605
Score: 0.219
Data Source: BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.991804345
p_ni: 0.008098435
p_wrong: 0.00009722
Score: 0.176
Data Source: BioPlex,STRINGDB
WRAP73
Tbio
Novelty: 0.25394934
p_int: 0.871391225
p_ni: 0.004243076
p_wrong: 0.124365699
Score: 0.181
Data Source: BioPlex,STRINGDB
KLHL10
Tdark
Novelty: 0.09497583
p_int: 0.860867872
p_ni: 0.031680857
p_wrong: 0.107451271
Score: 0.207
Data Source: BioPlex,STRINGDB
NLRX1
Tbio
Novelty: 0.00906898
p_int: 0.812224486
p_ni: 0.012288266
p_wrong: 0.175487248
Score: 0.16
Data Source: BioPlex,STRINGDB
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.02560954
p_int: 0.789679091
p_ni: 0.200965246
p_wrong: 0.009355663
Score: 0.175
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.33

PubMed score by year
PubTator Score  7.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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