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Tdark
ARSJ
Arylsulfatase J

Protein Summary
Description
Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315366
  • ENSP00000320219
  • ENSG00000180801

Symbol
  • ASJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
gene perturbation
0.75
histone modification site profile
0.64
microRNA
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.79   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.79   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (60)
1 – 10 of 60
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
Score:  0.973
Data Source:  STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
Score:  0.96
Data Source:  STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
Score:  0.949
Data Source:  STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
Score:  0.937
Data Source:  STRINGDB
ARSH
Tbio
Family:  Enzyme
Novelty:  0.03202479
Score:  0.932
Data Source:  STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
Score:  0.921
Data Source:  STRINGDB
ARSD
Tbio
Family:  Enzyme
Novelty:  0.00680724
Score:  0.921
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.92
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.92
Data Source:  STRINGDB
ARSF
Tbio
Family:  Enzyme
Novelty:  0.13109678
Score:  0.916
Data Source:  STRINGDB
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member J
VGNC:10820
471285
Macaque
arylsulfatase family member J
702633
Mouse
MGI:2443513
271970
Dog
arylsulfatase family member J
VGNC:38145
487909
Horse
arylsulfatase family member J
VGNC:15550
100072604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member J
Macaque
arylsulfatase family member J
Mouse
Dog
arylsulfatase family member J
Horse
arylsulfatase family member J
Publication Statistics
PubMed Score 139.79
PubMed score by year
PubTator Score 1.70
PubTator score by year