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Tbio
ESCO1
N-acetyltransferase ESCO1

Protein Summary
Description
Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269214
  • ENSP00000269214
  • ENSG00000141446
  • ENST00000383276
  • ENSP00000372763

Symbol
  • EFO1
  • KIAA1911
  • CTF
  • ECO1
  • EFO1
  • ESO1
  • A930014I12Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
histone modification site profile
0.7
gene perturbation
0.68
pathway
0.65
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
SMC3
Tbio
Novelty:  0.00474377
Score:  0.999
Data Source:  STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
Score:  0.993
Data Source:  Reactome,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.986
Data Source:  Reactome,STRINGDB
RAD21
Tbio
Novelty:  0.00270936
Score:  0.986
Data Source:  STRINGDB
SMC1A
Tchem
Novelty:  0.00898427
Score:  0.984
Data Source:  STRINGDB
PDS5B
Tbio
Novelty:  0.00295057
Score:  0.979
Data Source:  Reactome,STRINGDB
STAG1
Tbio
Novelty:  0.00122511
Score:  0.978
Data Source:  STRINGDB
STAG2
Tbio
Novelty:  0.00430441
Score:  0.974
Data Source:  STRINGDB
CHTF18
Tbio
Novelty:  0.02470494
Score:  0.944
Data Source:  STRINGDB
NIPBL
Tbio
Novelty:  0.00462654
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
S Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Establishment of Sister Chromatid Cohesion
S Phase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
establishment of sister chromatid cohesion N-acetyltransferase 1
VGNC:5167
468494
Macaque
establishment of sister chromatid cohesion N-acetyltransferase 1
698845
Mouse
MGI:1925055
77805
Rat
RGD:1596873
680014
Dog
establishment of sister chromatid cohesion N-acetyltransferase 1
VGNC:40470
490523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
establishment of sister chromatid cohesion N-acetyltransferase 1
Macaque
establishment of sister chromatid cohesion N-acetyltransferase 1
Mouse
Rat
Dog
establishment of sister chromatid cohesion N-acetyltransferase 1
Publication Statistics
PubMed Score 74.42
PubMed score by year
PubTator Score 28.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title