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Tbio
ZRANB3
DNA annealing helicase and endonuclease ZRANB3

Protein Summary
Description
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264159
  • ENSP00000264159
  • ENSG00000121988
  • ENST00000401392
  • ENSP00000383979
  • ENST00000619650
  • ENSP00000480120

Symbol
  • AH2
  • 4933425L19Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
histone modification site profile
0.87
transcription factor binding site profile
0.74
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.42   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.42   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sudden cardiac arrest
1
1
0
1.6
73.3
1
1
0
1.6
73.3
1
1
1
59.3
low density lipoprotein cholesterol measurement
1
1
1
34.8
hip circumference
1
1
1
24.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sudden cardiac arrest
0
1.6
73.3
0
1.6
73.3
1
59.3
low density lipoprotein cholesterol measurement
1
34.8
hip circumference
1
24.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 3
VGNC:14168
459629
Macaque
zinc finger RANBP2-type containing 3
712445
Mouse
MGI:1918362
226409
Rat
RGD:1564952
304761
Dog
zinc finger RANBP2-type containing 3
VGNC:48849
476128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 3
Macaque
zinc finger RANBP2-type containing 3
Mouse
Rat
Dog
zinc finger RANBP2-type containing 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5FWF4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.999993691
p_ni: 0.000006287
p_wrong: 2.2e-8
Score: 0.207
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.999631106
p_ni: 0.00030674
p_wrong: 0.000062154
Score: 0.211
Data Source: BioPlex,STRINGDB
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.999211846
p_ni: 0.000736172
p_wrong: 0.000051982
Data Source: BioPlex
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.998898329
p_ni: 0.000869509
p_wrong: 0.000232162
Data Source: BioPlex
TIGIT
Tbio
Novelty: 0.0064542
p_int: 0.998523984
p_ni: 0.001210499
p_wrong: 0.000265517
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.998448249
p_ni: 0.000883792
p_wrong: 0.000667958
Data Source: BioPlex
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
p_int: 0.996368929
p_ni: 0.000059559
p_wrong: 0.003571512
Score: 0.16
Data Source: BioPlex,STRINGDB
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.981826206
p_ni: 0.002156759
p_wrong: 0.016017035
Score: 0.2
Data Source: BioPlex,STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.975834835
p_ni: 0.002894782
p_wrong: 0.021270382
Data Source: BioPlex
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.870166475
p_ni: 0.02118644
p_wrong: 0.108647084
Data Source: BioPlex
Publication Statistics
PubMed Score  246.42

PubMed score by year
PubTator Score  97.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer