Tbio ZRANB3 DNA annealing helicase and endonuclease ZRANB3

Protein Summary

Description

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).

Uniprot Accession IDs

• Q5FWF4
• B3KYA1
• B4E375
• B5MDI3
• D3DP76
• E9PBP0
• Q53SM1
• Q6P2C4
• Q8N1P4
• Q9H0E8

Gene Name

• ZRANB3

Ensembl ID

• ENST00000264159
• ENSP00000264159
• ENSG00000121988
• ENST00000401392
• ENSP00000383979
• ENST00000619650
• ENSP00000480120

Symbol

• AH2
• 4933425L19Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.92
histone modification site profile	0.87
transcription factor binding site profile	0.74
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.38   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.38   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0