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Tbio
SGO1
Shugoshin 1

Protein Summary
Description
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometapha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263753
  • ENSP00000263753
  • ENSG00000129810
  • ENST00000306698
  • ENSP00000306581
  • ENST00000412997
  • ENSP00000410458
  • ENST00000417364
  • ENSP00000394613
  • ENST00000419233
  • ENSP00000394625
  • ENST00000421451
  • ENSP00000414129
  • ENST00000425061
  • ENSP00000414960
  • ENST00000437051
  • ENSP00000389034
  • ENST00000442720
  • ENSP00000394957
  • ENST00000443724
  • ENSP00000413070
  • ENST00000452020
  • ENSP00000411200

Symbol
  • SGOL1
  • SGO
  • CAID
  • SGOL1
  • NY-BR-85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.61   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.61   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999967804
p_ni:  0.000003483
p_wrong:  0.000028713
Score:  0.997
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.998499645
p_ni:  6.33e-7
p_wrong:  0.001499722
Score:  0.94
Data Source:  BioPlex,STRINGDB
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.922397936
p_ni:  0.000009222
p_wrong:  0.077592841
Score:  0.256
Data Source:  BioPlex,STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.997
Data Source:  STRINGDB
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
Score:  0.997
Data Source:  STRINGDB
AURKB
Tchem
Family:  Kinase
Novelty:  0.00100972
Score:  0.996
Data Source:  STRINGDB
CDCA8
Tbio
Novelty:  0.01448513
Score:  0.996
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.994
Data Source:  STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.994
Data Source:  STRINGDB
SKA1
Tbio
Novelty:  0.01777146
Score:  0.993
Data Source:  STRINGDB
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
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GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
2
3
94.2
mean reticulocyte volume
1
1
1
86
mean corpuscular hemoglobin concentration
1
1
1
82.3
reticulocyte measurement
2
2
2
71.1
reticulocyte count
2
1
2
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
94.2
mean reticulocyte volume
1
86
mean corpuscular hemoglobin concentration
1
82.3
reticulocyte measurement
2
71.1
reticulocyte count
2
69.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shugoshin 1
VGNC:9698
460220
Macaque
shugoshin 1
698231
Mouse
MGI:1919665
72415
Rat
RGD:1593238
363174
Dog
shugoshin 1
VGNC:46100
610343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shugoshin 1
Macaque
shugoshin 1
Mouse
Rat
Dog
shugoshin 1
Publication Statistics
PubMed Score 103.61
PubMed score by year
PubTator Score 59.00
PubTator score by year
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Related Publications
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PMID
Year
Title