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Tdark
DNAJC21
DnaJ homolog subfamily C member 21

Protein Summary
Description
May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342382
  • ENSP00000343728
  • ENSG00000168724
  • ENST00000382021
  • ENSP00000371451
  • ENST00000642851
  • ENSP00000496545
  • ENST00000648817
  • ENSP00000497410

Symbol
  • DNAJA5
  • GS3
  • JJJ1
  • BMFS3
  • DNAJA5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
protein domain
0.85
ligand (protein) perturbation
0.83
cell type or tissue
0.78
tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.998859218
p_ni:  2.4e-8
p_wrong:  0.001140758
Data Source:  BioPlex
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.986074275
p_ni:  1.22e-7
p_wrong:  0.013925603
Data Source:  BioPlex
ZNF622
Tbio
Novelty:  0.26258288
Score:  0.834
Data Source:  STRINGDB
DNAJC24
Tbio
Novelty:  0.09398707
Score:  0.818
Data Source:  STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
Score:  0.817
Data Source:  STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
Score:  0.78
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.771
Data Source:  STRINGDB
HSCB
Tbio
Novelty:  0.01330125
Score:  0.748
Data Source:  STRINGDB
DNAJC8
Tbio
Novelty:  0.27669763
Score:  0.698
Data Source:  STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
4
11
98.2
symmetrical dimethylarginine measurement
1
1
1
81.5
3-hydroxyisobutyrate measurement
1
1
1
76.3
3-aminoisobutyrate measurement
1
1
1
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
11
98.2
symmetrical dimethylarginine measurement
1
81.5
3-hydroxyisobutyrate measurement
1
76.3
3-aminoisobutyrate measurement
1
76.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C21
VGNC:7410
461926
Macaque
DnaJ heat shock protein family (Hsp40) member C21
699118
Mouse
MGI:1925371
78244
Rat
RGD:621729
192210
Dog
DnaJ heat shock protein family (Hsp40) member C21
479364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C21
Macaque
DnaJ heat shock protein family (Hsp40) member C21
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C21
Publication Statistics
PubMed Score 18.11
PubMed score by year
PubTator Score 27.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title