Tbio FLG2 Filaggrin-2

Protein Summary

Description

The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q5D862
• Q9H4U1
• FLG-2

Gene Name

• FLG2

Ensembl ID

• ENST00000388718
• ENSP00000373370
• ENSG00000143520

Symbol

• IFPS
• IFPS
• PSS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
protein domain	0.85
protein complex	0.84
cell type or tissue	0.82
cell line	0.61

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Filaggrin-2

DTO Classes

Protein / Cellular Structure / Filaggrin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.95   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.95   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0