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Tdark
TMEM128
Transmembrane protein 128

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GENEVA
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
6.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 128
VGNC:726
461088
Macaque
transmembrane protein 128 [Source:HGNC Symbol;Acc:HGNC:28201]
Mouse
MGI:1913559
66309
Rat
RGD:1310481
360952
Dog
transmembrane protein 128
VGNC:47462
479094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 128
Macaque
transmembrane protein 128 [Source:HGNC Symbol;Acc:HGNC:28201]
Mouse
Rat
Dog
transmembrane protein 128
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5BJH2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999997691
p_ni:  0.000002309
Score:  0.641
Data Source:  BioPlex,STRINGDB
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.999952679
p_ni:  0.000047321
Score:  0.195
Data Source:  BioPlex,STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.99995118
p_ni:  0.000036385
p_wrong:  0.000012435
Score:  0.165
Data Source:  BioPlex,STRINGDB
CD226
Tbio
Novelty:  0.00374102
p_int:  0.999651191
p_ni:  2.22e-7
p_wrong:  0.000348587
Data Source:  BioPlex
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.9996495
p_ni:  0.000350493
p_wrong:  7e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.998974482
p_ni:  0.001025462
p_wrong:  5.6e-8
Score:  0.356
Data Source:  BioPlex,STRINGDB
FUNDC2
Tbio
Novelty:  0.09695817
p_int:  0.997680417
p_ni:  0.00174486
p_wrong:  0.000574723
Score:  0.165
Data Source:  BioPlex,STRINGDB
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.997070701
p_ni:  0.002814752
p_wrong:  0.000114547
Score:  0.542
Data Source:  BioPlex,STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
p_int:  0.99414319
p_ni:  0.005856786
p_wrong:  2.3e-8
Data Source:  BioPlex
TMEM208
Tdark
Novelty:  0.63059333
p_int:  0.993029646
p_ni:  0.000130039
p_wrong:  0.006840315
Score:  0.719
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.16

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer