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Tbio
ODF2
Outer dense fiber protein 2

Protein Summary
Description
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351030
  • ENSP00000342581
  • ENSG00000136811
  • ENST00000372791
  • ENSP00000361877
  • ENST00000372807
  • ENSP00000361893
  • ENST00000372814
  • ENSP00000361901
  • ENST00000393527
  • ENSP00000377161
  • ENST00000393533
  • ENSP00000377166
  • ENST00000434106
  • ENSP00000403453
  • ENST00000444119
  • ENSP00000394506
  • ENST00000448249
  • ENSP00000396687
  • ENST00000546203
  • ENSP00000437579
  • ENST00000604420
  • ENSP00000473949

Symbol
  • CT134
  • ODF84
  • ODF2/1
  • ODF2/2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor
0.82
small molecule perturbation
0.8
kinase perturbation
0.71
histone modification site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.29   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.29   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
9.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
outer dense fiber of sperm tails 2
717505
Mouse
MGI:1098824
18286
Rat
RGD:3229
29479
Dog
outer dense fiber of sperm tails 2
VGNC:44099
491315
Horse
outer dense fiber of sperm tails 2
VGNC:21008
100070205
Species
Name
OMA
EggNOG
Inparanoid
Macaque
outer dense fiber of sperm tails 2
Mouse
Rat
Dog
outer dense fiber of sperm tails 2
Horse
outer dense fiber of sperm tails 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5BJF6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (165)
1 – 10 of 165
ODF2L
Tdark
Novelty:  0.56986705
p_int:  0.999999839
p_ni:  1.27e-7
p_wrong:  3.4e-8
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999999067
p_ni:  8.64e-7
p_wrong:  6.8e-8
Data Source:  BioPlex
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.999991298
p_ni:  8.33e-7
p_wrong:  0.000007869
Score:  0.173
Data Source:  BioPlex,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.999901227
p_ni:  0.000012282
p_wrong:  0.000086491
Score:  0.19
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.99938126
p_ni:  0.00001608
p_wrong:  0.000602659
Data Source:  BioPlex
PIBF1
Tbio
Novelty:  0.0454209
p_int:  0.998756687
p_ni:  0.001228866
p_wrong:  0.000014446
Data Source:  BioPlex
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.763869642
p_ni:  0.236130358
Score:  0.963
Data Source:  BioPlex,STRINGDB
PCNT
Tbio
Novelty:  0.00369505
Score:  0.973
Data Source:  STRINGDB
CNTRL
Tbio
Novelty:  0.01245179
Score:  0.971
Data Source:  STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.968
Data Source:  STRINGDB
Publication Statistics
PubMed Score  32.29

PubMed score by year
PubTator Score  23.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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