Tbio SPRN Shadow of prion protein

Protein Summary

Description

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Uniprot Accession IDs

• Q5BIV9
• Protein shadoo

Gene Name

• SPRN

Ensembl ID

• ENST00000414069
• ENSP00000433712
• ENSG00000203772

Symbol

• SHO
• SHO
• SHADOO
• bA108K14.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
cellular component	0.74
cell type or tissue	0.57
tissue sample	0.57
cell line	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.09   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.09   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0