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Tbio
SPRN
Shadow of prion protein

Protein Summary
Description
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414069
  • ENSP00000433712
  • ENSG00000203772

Symbol
  • SHO
  • SHO
  • SHADOO
  • bA108K14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
cellular component
0.74
cell type or tissue
0.57
tissue sample
0.57
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
67.3
coffee consumption measurement
2
1
2
62.1
tea consumption measurement
1
1
1
62.1
blood metabolite measurement
1
1
1
57.8
longevity
1
1
0
3.5
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
67.3
coffee consumption measurement
2
62.1
tea consumption measurement
1
62.1
blood metabolite measurement
1
57.8
longevity
0
3.5
40.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shadow of prion protein
739923
Mouse
MGI:3582583
212518
Rat
RGD:1561845
541462
Dog
shadow of prion protein
VGNC:46764
100855950
Cow
shadow of prion protein
VGNC:35239
616266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shadow of prion protein
Mouse
Rat
Dog
shadow of prion protein
Cow
shadow of prion protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5BIV9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (81)
1 – 10 of 81
PRND
Tbio
Novelty:  0.00645201
Score:  0.979
Data Source:  STRINGDB
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
Score:  0.946
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.906
Data Source:  STRINGDB
RTN4RL2
Tbio
Novelty:  0.05919593
Score:  0.905
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.905
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.905
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.905
Data Source:  STRINGDB
MDGA1
Tbio
Novelty:  0.04478487
Score:  0.904
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.904
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.75

PubMed score by year
PubTator Score  27.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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