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Tchem
TNNI3K
Serine/threonine-protein kinase TNNI3K

Protein Summary
Description
May play a role in cardiac physiology. This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326637
  • ENSP00000322251
  • ENSG00000116783

Symbol
  • CARK
  • CARK
  • TNNI3K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.9
trait
0.75
cell type or tissue
0.53
tissue
0.53
cell line
0.5


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
chemical structure image
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
11
22
99.3
smoking status measurement
2
2
2
96
self reported educational attainment
1
1
1
87
smoking behaviour measurement
1
1
1
84.3
mathematical ability
1
1
1
80.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
22
99.3
smoking status measurement
2
96
self reported educational attainment
1
87
smoking behaviour measurement
1
84.3
mathematical ability
1
80.2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q59H18-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (57)
1 – 10 of 57
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.998003879
p_ni: 0.001954133
p_wrong: 0.000041988
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.994594482
p_ni: 0.005405518
Data Source: BioPlex
KLHL42
Tdark
Novelty: 0.25822395
p_int: 0.887717421
p_ni: 0.112279005
p_wrong: 0.000003574
Data Source: BioPlex
TNNI3
Tbio
Novelty: 0.00020053
Score: 0.89
Data Source: STRINGDB
LRRIQ3
Tdark
Novelty: 0.63243484
Score: 0.797
Data Source: STRINGDB
SEC16B
Tbio
Novelty: 0.04073621
Score: 0.716
Data Source: STRINGDB
GNPDA2
Tbio
Family: Enzyme
Novelty: 0.02712908
Score: 0.685
Data Source: STRINGDB
FAIM2
Tbio
Novelty: 0.02444421
Score: 0.676
Data Source: STRINGDB
QPCTL
Tchem
Family: Enzyme
Novelty: 0.04004484
Score: 0.67
Data Source: STRINGDB
TMEM18
Tbio
Novelty: 0.02382811
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.84

PubMed score by year
PubTator Score  0.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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