Tchem TNNI3K Serine/threonine-protein kinase TNNI3K

Protein Summary

Description

May play a role in cardiac physiology. This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q59H18
• Q17RN0
• Q49AR1
• Q6MZS9
• Q9Y2V6

Gene Name

• TNNI3K

Ensembl ID

• ENST00000326637
• ENSP00000322251
• ENSG00000116783

Symbol

• CARK
• CARK
• TNNI3K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.9
trait	0.75
cell type or tissue	0.53
tissue	0.53
cell line	0.5

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Hh498 Subfamily / Serine/threonine-protein Kinase Tnni3k

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.42   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.42   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 50

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1