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Tbio
AWAT1
Acyl-CoA wax alcohol acyltransferase 1

Protein Summary
Description
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374521
  • ENSP00000363645
  • ENSG00000204195

Symbol
  • DGA2
  • DGAT2L3
  • DGA2
  • DGAT2L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.83
cell type or tissue
0.7
tissue
0.43
cell line
0.4
cellular component
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
ELOVL2
Tbio
Novelty:  0.00665823
Score:  0.808
Data Source:  STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.793
Data Source:  STRINGDB
PDIK1L
Tdark
Family:  Kinase
Novelty:  0.4630487
Score:  0.708
Data Source:  STRINGDB
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.646
Data Source:  STRINGDB
ELOVL3
Tchem
Novelty:  0.02311655
Score:  0.646
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.643
Data Source:  STRINGDB
SOAT2
Tchem
Family:  Enzyme
Novelty:  0.01860981
Score:  0.636
Data Source:  STRINGDB
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
Score:  0.631
Data Source:  STRINGDB
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
Score:  0.577
Data Source:  STRINGDB
SREBF1
Tbio
Family:  TF
Novelty:  0.00055257
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Wax and plasmalogen biosynthesis
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Wax and plasmalogen biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA wax alcohol acyltransferase 1
VGNC:1429
465684
Mouse
MGI:3588200
245533
Rat
RGD:1587163
679520
Dog
acyl-CoA wax alcohol acyltransferase 1
VGNC:38321
491938
Horse
acyl-CoA wax alcohol acyltransferase 1
VGNC:15713
100056316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA wax alcohol acyltransferase 1
Mouse
Rat
Dog
acyl-CoA wax alcohol acyltransferase 1
Horse
acyl-CoA wax alcohol acyltransferase 1
Publication Statistics
PubMed Score 62.94
PubMed score by year
PubTator Score 24.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title