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Tbio
PLEKHG4
Puratrophin-1

Protein Summary
Description
Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360461
  • ENSP00000353646
  • ENSG00000196155
  • ENST00000379344
  • ENSP00000368649
  • ENST00000393966
  • ENSP00000462601
  • ENST00000427155
  • ENSP00000401118
  • ENST00000450733
  • ENSP00000398030
  • ENST00000563969
  • ENSP00000457086

Symbol
  • PRTPHN1
  • SCA4
  • PRTPHN1
  • ARHGEF44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.79
tissue sample
0.64
transcription factor binding site profile
0.6
protein domain
0.58
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.83   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.83   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999997996
p_ni:  0.000002004
Data Source:  BioPlex
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.999690457
p_ni:  0.000309542
Score:  0.159
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.99663139
p_ni:  0.00336861
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.995914653
p_ni:  0.004085347
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.995091517
p_ni:  0.004908483
Data Source:  BioPlex
C10orf91
Tdark
p_int:  0.973595024
p_ni:  0.026404976
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.928924619
p_ni:  0.071075381
Score:  0.226
Data Source:  BioPlex,STRINGDB
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.884470801
p_ni:  0.115529198
p_wrong:  2e-9
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.810719094
p_ni:  0.189280906
Data Source:  BioPlex
SPTBN2
Tbio
Novelty:  0.01183066
Score:  0.855
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
3
3
6
93.1
BMI-adjusted waist-hip ratio
5
3
9
77.1
BMI-adjusted waist circumference
5
5
8
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
6
93.1
BMI-adjusted waist-hip ratio
9
77.1
BMI-adjusted waist circumference
8
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G4
VGNC:5865
454164
Macaque
pleckstrin homology and RhoGEF domain containing G4
699160
Mouse
MGI:2142544
102075
Rat
RGD:1310790
307796
Dog
pleckstrin homology and RhoGEF domain containing G4
VGNC:44679
489759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G4
Macaque
pleckstrin homology and RhoGEF domain containing G4
Mouse
Rat
Dog
pleckstrin homology and RhoGEF domain containing G4
Publication Statistics
PubMed Score 94.83
PubMed score by year
PubTator Score 36.89
PubTator score by year
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Related Publications
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PMID
Year
Title