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Tbio
KHDC3L
KHDC3-like protein

Protein Summary
Description
The protein encoded by this gene belongs to the KHDC1 family, members of which contain an atypical KH domain that may not bind RNA like canonical KH domains. This gene is specifically expressed in the oocytes, and recent studies suggest that it may function as a regulator of genomic imprinting in the oocyte. Mutations in this gene are associated with recurrent biparental complete hydatidiform mole. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370367
  • ENSP00000359392
  • ENSG00000203908

Symbol
  • C6orf221
  • ECAT1
  • ECAT1
  • HYDM2
  • C6orf221
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
PubMedID
0.59
cell type or tissue
0.53
tissue
0.48
biological term
0.39


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
KHDC1
Tbio
Novelty:  0.13778027
Score:  0.931
Data Source:  STRINGDB
NLRP7
Tbio
Novelty:  0.01301125
Score:  0.837
Data Source:  STRINGDB
TLE6
Tbio
Novelty:  0.07734594
Score:  0.812
Data Source:  STRINGDB
NLRP5
Tbio
Novelty:  0.02441137
Score:  0.745
Data Source:  STRINGDB
NLRP2
Tbio
Novelty:  0.00787844
Score:  0.642
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.639
Data Source:  STRINGDB
ZNF296
Tbio
Family:  TF
Novelty:  0.25752975
Score:  0.608
Data Source:  STRINGDB
PADI6
Tbio
Family:  Enzyme
Novelty:  0.01829292
Score:  0.589
Data Source:  STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
Score:  0.578
Data Source:  STRINGDB
ZFP57
Tbio
Family:  TF
Novelty:  0.02250344
Score:  0.57
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
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1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KH domain containing 3 like, subcortical maternal complex member
VGNC:8167
462820
Macaque
KH domain containing 3 like, subcortical maternal complex member
715808
Mouse
MGI:1914241
66991
Dog
KH domain containing 3 like, subcortical maternal complex member
481879
Cow
KH domain containing 3 like, subcortical maternal complex member
VGNC:54441
616454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KH domain containing 3 like, subcortical maternal complex member
Macaque
KH domain containing 3 like, subcortical maternal complex member
Mouse
Dog
KH domain containing 3 like, subcortical maternal complex member
Cow
KH domain containing 3 like, subcortical maternal complex member
Publication Statistics
PubMed Score 28.16
PubMed score by year
PubTator Score 14.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title