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Tdark
TDRD12
Putative ATP-dependent RNA helicase TDRD12

Protein Summary
Description
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421545
  • ENSP00000390621
  • ENSG00000173809
  • ENST00000444215
  • ENSP00000416248

Symbol
  • ECAT8
  • ECAT8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell line
0.74
tissue
0.54
biological process
0.51
tissue sample
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (148)
1 – 10 of 148
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.988
Data Source:  STRINGDB
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.985
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.978
Data Source:  STRINGDB
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.975
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.969
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.967
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.965
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.958
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.957
Data Source:  STRINGDB
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
Score:  0.949
Data Source:  STRINGDB
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7
9
10.9
98.5
urinary metabolite measurement
5
4
15
94.1
creatinine measurement
6
7
9
91.8
hemoglobin measurement
2
2
2
87.2
urate measurement
4
4
4
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
10.9
98.5
urinary metabolite measurement
15
94.1
creatinine measurement
9
91.8
hemoglobin measurement
2
87.2
urate measurement
4
86.5
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 12
455925
Macaque
tudor domain containing 12
702953
Mouse
MGI:1919231
71981
Rat
RGD:1562792
689639
Dog
tudor domain containing 12
VGNC:47221
612696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 12
Macaque
tudor domain containing 12
Mouse
Rat
Dog
tudor domain containing 12
Publication Statistics
PubMed Score 3.77
PubMed score by year
PubTator Score 1.79
PubTator score by year