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Tchem
MAP3K19
Mitogen-activated protein kinase kinase kinase 19

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358371
  • ENSP00000351140
  • ENSG00000176601
  • ENST00000375844
  • ENSP00000365004
  • ENST00000375845
  • ENSP00000365005
  • ENST00000392915
  • ENSP00000376647
  • ENST00000392917
  • ENSP00000376649
  • ENST00000392918
  • ENSP00000376650

Symbol
  • RCK
  • YSK4
  • RCK
  • YSK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.73
biological process
0.62
cell type or tissue
0.56
cell line
0.49


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
2
2
92.4
gut microbiome measurement
5
3
0
7.2
87.5
grip strength measurement
2
2
2
71.8
red blood cell density measurement
1
1
1
66.8
vital capacity
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
92.4
gut microbiome measurement
0
7.2
87.5
grip strength measurement
2
71.8
red blood cell density measurement
1
66.8
vital capacity
1
62.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 19
VGNC:1995
470547
Macaque
mitogen-activated protein kinase kinase kinase 19
712728
Mouse
MGI:1203481
22625
Rat
Dog
mitogen-activated protein kinase kinase kinase 19 [Source:HGNC Symbol;Acc:HGNC:26249]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 19
Macaque
mitogen-activated protein kinase kinase kinase 19
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 19 [Source:HGNC Symbol;Acc:HGNC:26249]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q56UN5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
DYRK1B
Tchem
Family:  Kinase
Novelty:  0.01960932
Score:  0.637
Data Source:  STRINGDB
SGK494
Tdark
Family:  Kinase
Novelty:  1.64952942
Score:  0.579
Data Source:  STRINGDB
ZRANB3
Tbio
Family:  Enzyme
Novelty:  0.00398767
Score:  0.537
Data Source:  STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
Score:  0.529
Data Source:  STRINGDB
CENPL
Tbio
Novelty:  0.18429095
Score:  0.527
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.524
Data Source:  STRINGDB
CCNT2
Tbio
Novelty:  0.04593314
Score:  0.521
Data Source:  STRINGDB
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
Score:  0.52
Data Source:  STRINGDB
EIF2D
Tbio
Novelty:  0.03765592
Score:  0.515
Data Source:  STRINGDB
TOR1AIP1
Tbio
Novelty:  0.09110893
Score:  0.514
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.82

PubMed score by year
PubTator Score  61.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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