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Tbio
ESCO2
N-acetyltransferase ESCO2

Protein Summary
Description
Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305188
  • ENSP00000306999
  • ENSG00000171320
  • ENST00000397418
  • ENSP00000380563

Symbol
  • RBS
  • EFO2
  • EFO2p
  • hEFO2
  • 2410004I17Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cellular component
0.81
transcription factor perturbation
0.74
tissue sample
0.67
interacting protein
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
SMC3
Tbio
Novelty:  0.00474377
Score:  0.998
Data Source:  STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
Score:  0.992
Data Source:  Reactome,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.986
Data Source:  Reactome,STRINGDB
SMC1A
Tchem
Novelty:  0.00898427
Score:  0.984
Data Source:  STRINGDB
PDS5B
Tbio
Novelty:  0.00295057
Score:  0.982
Data Source:  Reactome,STRINGDB
RAD21
Tbio
Novelty:  0.00270936
Score:  0.982
Data Source:  STRINGDB
STAG1
Tbio
Novelty:  0.00122511
Score:  0.973
Data Source:  STRINGDB
STAG2
Tbio
Novelty:  0.00430441
Score:  0.97
Data Source:  STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.951
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
S Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Establishment of Sister Chromatid Cohesion
S Phase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
establishment of sister chromatid cohesion N-acetyltransferase 2
VGNC:1171
472926
Macaque
establishment of sister chromatid cohesion N-acetyltransferase 2
713186
Mouse
MGI:1919238
71988
Dog
establishment of sister chromatid cohesion N-acetyltransferase 2
VGNC:40471
486098
Horse
establishment of sister chromatid cohesion N-acetyltransferase 2
VGNC:17679
100060754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
establishment of sister chromatid cohesion N-acetyltransferase 2
Macaque
establishment of sister chromatid cohesion N-acetyltransferase 2
Mouse
Dog
establishment of sister chromatid cohesion N-acetyltransferase 2
Horse
establishment of sister chromatid cohesion N-acetyltransferase 2
Publication Statistics
PubMed Score 53.78
PubMed score by year
PubTator Score 86.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title