C2CD6
C2 calcium-dependent domain-containing protein 6
Protein Summary
An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The encoded protein contains a calcium-dependent membrane targeting C2 domain. This domain is often found in proteins that are involved in membrane trafficking and signal transduction. [provided by RefSeq, Jun 2016]
- ENST00000286195
- ENSP00000286195
- ENSG00000155754
- ENST00000439140
- ENSP00000409937
- ENST00000439802
- ENSP00000400672
- ENST00000450242
- ENSP00000399016
- ALS2CR11
- ALS2CR11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.45 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.45 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (0)
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 1 | 1 | 35 | |||||
1 | 1 | 0 | 1.1 | 21.5 | |||||
cocaine use disorder | 1 | 1 | 0 | 5.5 | 17.8 | ||||
social environment measurement | 1 | 1 | 0 | 5.5 | 17.8 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 35 | |||||
0 | 1.1 | 21.5 | |||||
cocaine use disorder | 0 | 5.5 | 17.8 | ||||
social environment measurement | 0 | 5.5 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | C2 calcium dependent domain containing 6 | VGNC:66 | 746584 | |||||
Macaque | amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein | 702140 | ||||||
Cow | C2 calcium dependent domain containing 6 | VGNC:26637 | 616081 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | C2 calcium dependent domain containing 6 | |||||
Macaque | amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein | |||||
Cow | C2 calcium dependent domain containing 6 | |||||
Publication Statistics
PubMed Score 0.45
PubMed score by year
PubTator Score 0.25
PubTator score by year
Related Publications
Text Mined References (9)
Items per page:
0 of 0
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