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Tbio
TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

Protein Summary
Description
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263663
  • ENSP00000263663
  • ENSG00000115750

Symbol
  • SL1
  • RAF1B
  • RAFI63
  • TAFI63
  • MGC:9349
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
kinase perturbation
0.81
biological process
0.66
cellular component
0.65
histone modification site profile
0.65


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.67   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.67   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit B
VGNC:10292
459022
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit B
701733
Mouse
MGI:109577
21340
Rat
RGD:1596058
690450
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit B
VGNC:47078
100684854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit B
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit B
Mouse
Rat
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q53T94-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Protein-Protein Interactions (128)
1 – 10 of 128
TAF1D
Tdark
Family: Enzyme
Novelty: 0.26072519
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
TRIM44
Tbio
Novelty: 0.00483553
p_int: 0.999956038
p_ni: 0.000043962
Score: 0.525
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999925101
p_ni: 0.000074899
Data Source: BioPlex
TAF1C
Tbio
Family: Enzyme
Novelty: 0.11112315
p_int: 0.999029985
p_ni: 0.000970015
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TAF1A
Tbio
Family: Enzyme
Novelty: 0.10734794
p_int: 0.993668392
p_ni: 0.006331357
p_wrong: 2.52e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.991380022
p_ni: 0.008619885
p_wrong: 9.4e-8
Score: 0.201
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.990917643
p_ni: 0.00906791
p_wrong: 0.000014448
Data Source: BioPlex
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.968548142
p_ni: 0.02616606
p_wrong: 0.005285798
Score: 0.647
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.966121377
p_ni: 0.033877685
p_wrong: 9.38e-7
Score: 0.511
Data Source: BioPlex,STRINGDB
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.958784615
p_ni: 0.041215091
p_wrong: 2.94e-7
Score: 0.522
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.67

PubMed score by year
PubTator Score  15.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer