You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TM4SF20
Transmembrane 4 L6 family member 20

Protein Summary
Description
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293). The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304568
  • ENSP00000303028
  • ENSG00000168955

Symbol
  • SLI5
  • PRO994
  • TCCE518
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
gene perturbation
0.71
cell line
0.63
microRNA
0.59
transcription factor
0.35


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
3
0
2.4
89.7
intraocular pressure measurement
2
3
3
80.7
hematocrit
1
1
1
53.7
corneal topography
1
1
1
35
myeloid white cell count
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.4
89.7
intraocular pressure measurement
3
80.7
hematocrit
1
53.7
corneal topography
1
35
myeloid white cell count
1
7.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 20
VGNC:2882
735656
Macaque
transmembrane 4 L six family member 20
708719
Mouse
MGI:1913511
66261
Rat
RGD:1588633
691066
Dog
transmembrane 4 L six family member 20
VGNC:47408
609780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 20
Macaque
transmembrane 4 L six family member 20
Mouse
Rat
Dog
transmembrane 4 L six family member 20
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q53R12-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (39)
1 – 10 of 39
CD74
Tchem
Novelty:  0.00281228
p_int:  0.999983356
p_ni:  0.000016409
p_wrong:  2.35e-7
Score:  0.29
Data Source:  BioPlex,STRINGDB
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.997691042
p_ni:  0.000633784
p_wrong:  0.001675174
Score:  0.243
Data Source:  BioPlex,STRINGDB
HSDL1
Tbio
Family:  Enzyme
Novelty:  0.24066595
p_int:  0.997059235
p_ni:  0.002940765
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM186
Tdark
Novelty:  0.59951294
p_int:  0.906447754
p_ni:  0.093552246
Score:  0.173
Data Source:  BioPlex,STRINGDB
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
p_int:  0.855281107
p_ni:  0.144619236
p_wrong:  0.000099657
Score:  0.183
Data Source:  BioPlex,STRINGDB
FAM241B
Tdark
Novelty:  0.70797589
p_int:  0.79430387
p_ni:  0.205695957
p_wrong:  1.73e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
EBP
Tchem
Family:  Enzyme
Novelty:  0.00610658
p_int:  0.755940944
p_ni:  0.241853526
p_wrong:  0.00220553
Score:  0.169
Data Source:  BioPlex,STRINGDB
TM4SF18
Tbio
Novelty:  0.16102348
Score:  0.675
Data Source:  STRINGDB
TTC16
Tdark
Novelty:  14.55737705
Score:  0.62
Data Source:  STRINGDB
GPA33
Tbio
Novelty:  0.0081206
Score:  0.613
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.82

PubMed score by year
PubTator Score  1.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer