You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGAP15
Rho GTPase-activating protein 15

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.87
trait
0.86
protein domain
0.73
kinase perturbation
0.71
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.999600234
p_ni:  0.000399766
Score:  0.252
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.956
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.955
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.941
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.941
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.937
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.929
Data Source:  STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
Score:  0.928
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.927
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
5
7
98.1
self reported educational attainment
5
7
7
7.7
95.4
diverticular disease
2
2
0
1.2
93.3
lymphocyte percentage of leukocytes
1
3
3
93.1
chronotype measurement
2
3
2
1
91
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
7
98.1
self reported educational attainment
7
7.7
95.4
diverticular disease
0
1.2
93.3
lymphocyte percentage of leukocytes
3
93.1
chronotype measurement
2
1
91
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 15
VGNC:74
459642
Macaque
Rho GTPase activating protein 15
705311
Mouse
MGI:1923367
76117
Rat
RGD:1359304
295635
Dog
Rho GTPase activating protein 15
VGNC:38047
476138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 15
Macaque
Rho GTPase activating protein 15
Mouse
Rat
Dog
Rho GTPase activating protein 15
Publication Statistics
PubMed Score 14.67
PubMed score by year
PubTator Score 3.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title