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Tbio
LBH
Protein LBH

Protein Summary
Description
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395323
  • ENSP00000378733
  • ENSG00000213626
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.82
gene perturbation
0.71
tissue
0.64
transcription factor
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
74
refractive error measurement
1
1
1
68.1
myeloid white cell count
1
1
1
50.8
red blood cell density measurement
1
1
1
48.3
hematocrit
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
74
refractive error measurement
1
68.1
myeloid white cell count
1
50.8
red blood cell density measurement
1
48.3
hematocrit
1
46.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
limb bud and heart development
704749
Mouse
MGI:1925139
77889
Rat
RGD:1584525
683626
Dog
limb bud and heart development
611237
Horse
limb bud and heart development
100070844
Species
Name
OMA
EggNOG
Inparanoid
Macaque
limb bud and heart development
Mouse
Rat
Dog
limb bud and heart development
Horse
limb bud and heart development
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q53QV2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (10)
1 – 10 of 10
EN1
Tbio
Family: TF
Novelty: 0.00490799
Score: 0.647
Data Source: STRINGDB
LMCD1
Tbio
Novelty: 0.06810419
Score: 0.596
Data Source: STRINGDB
LGALS4
Tchem
Novelty: 0.00021923
Score: 0.527
Data Source: STRINGDB
RIN2
Tbio
Novelty: 0.0527887
Score: 0.512
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.507
Data Source: STRINGDB
VGLL3
Tbio
Novelty: 0.04210787
Score: 0.458
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.429
Data Source: STRINGDB
HTR2B
Tclin
Family: GPCR
Novelty: 0.00237051
Score: 0.405
Data Source: STRINGDB
TMEM88B
Tdark
Novelty: 1.83653775
Score: 0.405
Data Source: STRINGDB
YPEL5
Tbio
Novelty: 0.26093125
Score: 0.4
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.46

PubMed score by year
PubTator Score  43.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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