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Tbio
CDCA8
Borealin

Protein Summary
Description
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327331
  • ENSP00000316121
  • ENSG00000134690
  • ENST00000373055
  • ENSP00000362146

Symbol
  • PESCRG3
  • BOR
  • DasraB
  • MESRGP
  • BOREALIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.85
cellular component
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.16   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.16   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
1
4
87.2
intraocular pressure measurement
2
1
2
53.3
mathematical ability
3
2
3
53.2
Malignant epithelial tumor of ovary
1
1
0
1.1
50.6
1
1
0
1.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
87.2
intraocular pressure measurement
2
53.3
mathematical ability
3
53.2
Malignant epithelial tumor of ovary
0
1.1
50.6
0
1.1
35
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 8
VGNC:473
456762
Macaque
cell division cycle associated 8
719808
Mouse
MGI:1196274
52276
Rat
RGD:1566306
500545
Dog
cell division cycle associated 8
VGNC:39017
608164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 8
Macaque
cell division cycle associated 8
Mouse
Rat
Dog
cell division cycle associated 8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53HL2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (344)
1 – 10 of 344
BIRC5
Tchem
Novelty:  0.00332112
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.99999953
p_ni:  3.98e-7
p_wrong:  7.3e-8
Data Source:  BioPlex
MYH3
Tbio
Novelty:  0.00544794
p_int:  0.999569486
p_ni:  0.000409041
p_wrong:  0.000021473
Score:  0.207
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.999295981
p_ni:  0.000703279
p_wrong:  7.4e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
VSNL1
Tbio
Novelty:  0.01221371
p_int:  0.998497519
p_ni:  0.001281879
p_wrong:  0.000220602
Score:  0.158
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.997477594
p_ni:  0.002476473
p_wrong:  0.000045933
Score:  0.19
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.995945436
p_ni:  0.000248317
p_wrong:  0.003806247
Data Source:  BioPlex
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
p_int:  0.994862657
p_ni:  0.000324726
p_wrong:  0.004812617
Score:  0.179
Data Source:  BioPlex,STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
p_int:  0.99115014
p_ni:  0.008849072
p_wrong:  7.89e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
p_int:  0.966072801
p_ni:  0.033927199
Score:  0.473
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  65.16

PubMed score by year
PubTator Score  52.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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